Evidence map›Paper›PMID 31894428›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2020

Barrett's esophagus patients are becoming younger: analysis of a large United States dataset.

Takahisa Yamasaki, Sasan Sakiani, Carla Maradey-Romero, Ripple Mehta, Dalbir Sandhu, Stephen Ganocy, Colin Hemond, Mohamed Eisa, Ronnie Fass

Abstract read
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In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. E-cigarette use and Barrett's esophagus: evaluating a new risk in the era of vaping.Esophagus : official journal of the Japan Esophageal Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Takahisa YamasakiDivision of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Sasan SakianiDivision of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Carla Maradey-RomeroDivision of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Ripple MehtaDivision of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Dalbir SandhuDivision of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Stephen GanocyDepartment of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Colin HemondDivision of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Mohamed EisaDepartment of Internal Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Ronnie FassDivision of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. ronnie.fass@gmail.com.ORCID 0000-0002-4807-3052
MetroHealth Medical Center · USUniversity School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBarrett's esophagus (BE), a complication of long-term gastroesophageal reflux disease (GERD), has been reported to affect 6-8% of those with heartburn. Most patients are males, Caucasians and middle aged. However, there are no recent demographic studies that evaluated the proportion trends of BE. We aimed to assess proportion trends of BE over an 11-year period, using a very large national dataset.

methodsThis was a population-based analysis of the national Explorys dataset. Explorys is an aggregate of electronic medical record database representing over 54 million patients. Proportions of BE's variables such as age, gender, race, BMI, and treatment with PPI were recorded during an 11-year period. BE patients were classified into seven age groups (15-19, 20-29, 30-39, 40-49, 50-59, 60-69, ≥ 70 years old). Secular trends of the proportion of BE were assessed over time for each age group.

resultsThe majority of patients diagnosed with BE were ≥ 70 years old across all calendar years. However, the proportion of BE patients who were ≥ 70 years old has significantly decreased between 2006 and 2016 (- 19.9%, p < 0.001). The proportion of patients with BE increased in all age groups but most prominently in the age groups, 30-39: 2.07%, 40-49: 3.64%, 50-59: 6.89%, 60-69: 6.18%, p < 0.001. BE was significantly more common in those who were Caucasian and male. PPI usage fell significantly in those who were ≥ 70 years old (- 20.8%, p < 0.001), but increased in the other remaining age groups.

conclusionsThe proportion of BE patients who are 70 years and older has significantly dropped. Younger patients' groups have demonstrated the highest increase in the proportion of BE patients, especially those in the age group of 30-39 years old.

Indexed as

AdolescentAdultAgedBarrett EsophagusCase-Control StudiesCohort StudiesData ManagementElectronic Health RecordsFemaleGastroesophageal RefluxHeartburnHumansMaleMiddle AgedPrevalenceProton Pump InhibitorsProton Pump InhibitorsAgeBarrett’s esophagusEpidemiologyPPI

Identifiers

PMID31894428
OpenAlexW2998552777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.