ArticleBrain structure & function2020
Human menstrual cycle variation in subcortical functional brain connectivity: a multimodal analysis approach.
Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.Scientific reports · 2023Trial
- Distinct intrinsic neural connectivity of an emotion regulation network across the menopausal transition.Comprehensive psychoneuroendocrinology · 2026Article
- Why does FND mainly affect women? A consideration of gender imbalance in neuropsychiatric disease.Psychological medicine · 2026Review
- Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.Psychological medicine · 2026Article
- The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women.Communications biology · 2026Article
- A standardized non-linear approach to studying menstrual cycle effects on brain and behavior.Frontiers in cognition · 2026Article
- Neuron soma size and density measurements in rat striatal regions disaggregated by sex and estrous cycle phase.Brain structure & function · 2025Article
- Females in Psychedelic Research: A Perspective for Advancing Research and Practice.ACS pharmacology & translational science · 2025Review
- Characteristics of the amygdala and its subregions in premenstrual syndrome/premenstrual dysphoric disorder patients.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Estradiol modulates resting-state connectivity in perimenopausal depression.Journal of affective disorders · 2025Article
- Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats.Frontiers in nutrition · 2025Article
- Assessing the association between menstrual cycle phase and voice-gender categorization: no robust evidence for an association.Frontiers in psychology · 2025Article
- PTSD-related differences in resting-state functional connectivity and associations with sex hormones.medRxiv : the preprint server for health sciences · 2024Article
- Fluctuation of fine motor skills throughout the menstrual cycle in women.Scientific reports · 2024Article
- Differential modulation of resting-state functional connectivity between amygdala and precuneus after acute physical exertion of varying intensity: indications for a role in affective regulation.Frontiers in human neuroscience · 2024Article
- Learning exceptions to category rules varies across the menstrual cycle.Scientific reports · 2023Article
- Metreleptin Robustly Increases Resting-state Brain Connectivity in Treatment-naïve Female Patients With Lipodystrophy.Journal of the Endocrine Society · 2023Article
- Stressor-Specific Sex Differences in Amygdala-Frontal Cortex Networks.Journal of clinical medicine · 2023Article
- High-amplitude network co-fluctuations linked to variation in hormone concentrations over the menstrual cycle.Network neuroscience (Cambridge, Mass.) · 2023Article
- Altered anterior insula functional connectivity in adolescent and young women with endometriosis-associated pain: Pilot resting-state fMRI study.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Increasing evidence suggests that endogenous sex steroid changes affect human brain functional connectivity, which could be obtained by resting-state fMRI (RS-fMRI). Nevertheless, RS studies on the menstrual cycle (MC) are underrepresented and yield inconsistent results. We attribute these inconsistencies to the use of various methods in exploratory approaches and small sample sizes. Hormonal fluctuations along the MC likely elicit subtle changes that, however, may still have profound impact on network dynamics when affecting key brain nodes. To address these issues, we propose a ROI-based multimodal analysis approach focusing on areas of high functional relevance to adequately capture these changes. To that end, sixty naturally cycling women underwent RS-fMRI in three different cycle phases and we performed the following analyses: (1) group-independent component analyses to identify intrinsic connectivity networks, (2) eigenvector centrality (EC) as a measure of centrality in the global connectivity hierarchy, (3) amplitude of low-frequency fluctuations (ALFF) as a measure of oscillatory activity and (4) seed-based analyses to investigate functional connectivity from the ROIs. For (2)-(4), we applied a hypothesis-driven ROI approach in the hippocampus, caudate and putamen. In the luteal phase, we found (1) decreased intrinsic connectivity of the right angular gyrus with the default mode network, (2) heightened EC for the hippocampus, and (3) increased ALFF for the caudate. Furthermore, we observed (4) stronger putamen-thalamic connectivity during the luteal phase and stronger fronto-striatal connectivity during the pre-ovulatory phase. This hormonal modulation of connectivity dynamics may underlie behavioural, emotional and sensorimotor changes along the MC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.