ArticleMolecular medicine reports2020
Phellinus gilvus‑derived protocatechualdehyde induces G0/G1 phase arrest and apoptosis in murine B16‑F10 cells.
Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Anticancer Secondary Metabolites Produced by Fungi: Potential and Representative Compounds.International journal of molecular sciences · 2025Review
- Unlocking the therapeutic potential of protocatechualdehyde: pharmacological applications and mechanism insights.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Antibacterial and antibiofilm activities of protocatechualdehyde and its synergy with ampicillin against methicillin-resistantFrontiers in microbiology · 2024Article
- Uncovering pharmacological mechanisms of Phellinus linteus on focal segmental glomeruloscleosis rats through tandem mass tag-based quantitative proteomic analysis, network pharmacology analysis and experimental validation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Phenolic profile, antioxidation and anti-proliferation activity of phenolic-rich extracts fromCurrent research in food science · 2023Article
- Alcohol extracts of Chinese bayberry branch induce S-phase arrest and apoptosis in HepG2 cells.Food science & nutrition · 2023Article
- EngineeredFrontiers in bioengineering and biotechnology · 2022Article
- Investigation of the mechanism of the anti-cancer effects ofFrontiers in pharmacology · 2022Article
- Non-targeted metabonomics and transcriptomics revealed the mechanism of mulberry branch extracts promoting the growth ofFrontiers in microbiology · 2022Article
- Aqueous extracts ofOncology letters · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protocatechualdehyde (PCA) is considered to be the main phenolic component of Phellinus gilvus responsible for its anticancer properties. Previous studies have demonstrated that PCA can have an anticancer effect on multiple cancer types, but little is known about the effect of PCA on melanoma cells. The present study investigated the inhibitory abilities and potential anticancer mechanisms of PCA on B16‑F10 cells using MTT assay. Cell apoptosis and cell cycle were assessed by flow cytometry using Annexin V‑FITC and propidium iodide staining. Whole‑transcriptome analysis was used to investigate the effects of PCA on gene expression. PCA significantly decreased cell viability, induced cell cycle arrest at G0/G1 phase and promoted apoptosis of B16‑F10 cells, suggesting that PCA could have anticancer effects against melanoma cells. Whole‑transcriptome analysis indicated that PCA treatment upregulated genes involved in histone modification and decreased the transcription of genes involved in DNA repair and replication. Kyoto Encyclopedia of Genes and Genomes analysis showed that PCA treatment enhanced the complement and coagulation cascades, and the p53 signaling pathway. The present results indicated that PCA could act as an antitumor agent in melanoma cells, which may provide experimental support for the development of novel therapies to treat melanoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.