Evidence map›Paper›PMID 31894288›Full record

ArticleInternational journal of molecular medicine2020

miRNA‑384‑5p regulates the progression of Parkinson's disease by targeting SIRT1 in mice and SH‑SY5Y cell.

Hongli Tao, Yan Liu, Yingjuan Hou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Unlocking Parkinson's disease: the role of microRNAs in regulation, diagnosis, and therapy.Apoptosis : an international journal on programmed cell death · 2025
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  17. Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson's Disease.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Hongli TaoDepartment of Psychiatry, Xianyang Central Hospital, Xianyang, Shaanxi 712000, P.R. China.
Yan LiuDepartment of Neurology, Weinan Central Hospital, Weinan, Shaanxi 714000, P.R. China.
Yingjuan HouDepartment of Neurology, The First Hospital of Yulin, Yulin, Shaanxi 718000, P.R. China.
Weinan Central Hospital · CNXian Yang Central Hospital · CNYulin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. miR‑384‑5p expression has been shown to be increased in an in vitro model of PD; however, it remains unknown whether there are other molecules that can be regulated by miR‑384‑5p in in vivo and in vitro models of PD; thus, the present study aimed to elucidate this matter. Rotenone was applied for the establishment of in vitro and in vivo models of PD in the present study. Motor disability and equilibrium were determined by a swimming test and traction test, respectively. mRNA and protein levels were detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis, respectively. The association between miR‑384‑5p and Sirtuin 1 (SIRT1) expression was verified by dual luciferase reporter assay. The α‑synuclein aggregation was evaluated by immunofluorescence. The results from the in vitro model of PD demonstrated that, the mice in the PD group exhibited decreased scores in the swimming test and traction test, which were accompanied by increased α‑synuclein aggregation. In addition, the expression of miR‑384‑5p, which targeted the 3'untranslated region (3'UTR) of SIRT1, was verified to be increased in mice and SH‑SY5Y cells in the PD group, whereas SIRT1 exhibited the opposite changes. Moreover, increased mRNA and protein levels of p53 and FOXO1 were observed in mice and SH‑SY5Y cells in the PD group. In addition, the SH‑SY5Y cells in the PD group exhibited a higher cell apoptotic rate. On the whole, the findings of this study demonstrate that miRNA‑384‑5p promotes the progression of PD by targeting SIRT1.

Indexed as

3' Untranslated RegionsAnimalsCell Line, TumorDisease ProgressionGene Expression RegulationHumansMaleMiceMice, Inbred C57BLMicroRNAsParkinson DiseaseSirtuin 13' Untranslated RegionsMicroRNAsMIRN384 microRNA, humanMIRN384 microRNA, mouseSIRT1 protein, humanSirt1 protein, mouseSirtuin 1

Identifiers

PMID31894288
PMCPMC6984790
OpenAlexW2994619708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.