Evidence map›Paper›PMID 31894111›Full record

ArticleJournal of biosciences2019

Rational design of type-IA receptor-derived cyclic peptides to target human bone morphogenic protein 2.

Xiaohua Fan, Hai Xia, Xiaoyun Liu, Benying Li, Jun Fang

Abstract read
PubMed
In one paragraph

Article in Journal of biosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaohua FanDepartment of Joint and Trauma Surgery, Yidu Central Hospital, Weifang Medical University, Qingzhou 262500, China.
Hai Xia
Xiaoyun Liu
Benying Li
Jun Fang
Weifang Medical University · CNYidu Central Hospital of Weifang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human bone morphogenetic protein 2 (BMP2) is a bone-growth regulatory factor involved in the formation of bone and cartilage, and has been recogn ized as an attractive therapeutic target for a variety of bone diseases and defects. Here, we report successful design of a head-to-tail cyclic peptide based on crystal structure to target BMP2. Computational alanine scanning identifies two hotspot regions at the crystal complex interface of BMP2 with its type-IA receptor; promising one is stripped from the interface to derive a linear self-inhibitory peptide RPS2

Indexed as

AlanineBone DevelopmentBone Morphogenetic Protein 2CartilageCrystallography, X-RayHumansMolecular Dynamics SimulationMultiprotein ComplexesPeptides, CyclicProtein ConformationRibosomal ProteinsSignal TransductionAlanineBMP2 protein, humanBone Morphogenetic Protein 2Multiprotein ComplexesPeptides, CyclicRibosomal ProteinsRPS2 protein, human

Identifiers

PMID31894111
OpenAlexW2982034321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.