ArticleAnnals of surgical oncology2020
Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort.
Article in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Clinical impact of the neutrophil-to-lymphocyte ratio on survival in patients with colorectal cancer according to stage: a retrospective study.Surgery today · 2026Article
- The Prognostic Role of Postoperative Inflammation After Minimally Invasive Resection for Colorectal Cancer.Annals of surgical oncology · 2026Article
- The role of the lymphatic network in colorectal cancer: anatomy, molecular drivers and management.Annals of gastroenterology · 2026Review
- Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative Group.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Hsa_circ_0101050 accelerates the progression of Colon cancer by targeting the miR-140-3 p/MELK axis.Translational oncology · 2024Article
- Intratumor APOL3 delineates a distinctive immunogenic ferroptosis subset with prognosis prediction in colorectal cancer.Cancer science · 2024Article
- Low ferroptosis score predicts chemotherapy responsiveness and immune-activation in colorectal cancer.Cancer medicine · 2023Article
- Prognostic Value of Post-Operative C-Reactive Protein-Based Inflammatory Biomarkers in Colorectal Cancer Patients: Systematic Review and Meta-Analysis.Clinical epidemiology · 2023Review
- Article
- Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I-III colorectal cancer: a retrospective cohort study.Updates in surgery · 2022Article
- Prognostic Factor and Survival Benefit of Adjuvant Chemotherapy in Stage IIA Colon Cancer.Annals of coloproctology · 2021Article
- Recurrence Risk after Radical Colorectal Cancer Surgery-Less Than before, But How High Is It?Cancers · 2020Review
- Review
- circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway.Aging · 2020Observational
- ASO Author Reflections: Emerging Risk Factors in Colon Cancer-End of the Line for Clinomics?Annals of surgical oncology · 2020Article
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4 authors.
Funding
Abstract
backgroundThe purpose of this study was to investigate whether pT3-4 and pN-subclassifications, lymph-node ratio (LNR), tumour deposits, pre- and postoperative carcinoembryonic antigen (CEA), and C-reactive protein (CRP)-all parameters commonly collected in clinical management-add information about recurrence risk against a background of routine clinicopathological parameters as defined by the NCCN.
methodsThe prospective cohort consisted of all 416 patients diagnosed with colon cancer stage I-III in Uppsala County between 2010 and 2015. Cox proportional hazard models were used to calculate hazard ratios for time to recurrence and overall survival. The results were compared with the entire Swedish population concerning parameters recorded in the national quality registry, SCRCR, during the same time period.
resultsThe Uppsala cohort was representative of the entire Swedish cohort. In unadjusted analyses, pT3-subclassification, pN-subclassification, LNR, tumour deposits, elevated postoperative CEA, and preoperative CRP correlated with recurrence. After adjusting for T-, N-stage, and NCCN risk factors, pN-subclassification, sidedness, and elevated postoperative CEA levels correlated with recurrence. Survival correlated with parameters associated with recurrence, LNR, and elevated postoperative CRP.
conclusionsAdditional information on recurrence risk is available from several routinely recorded parameters, but most of the risk is predicted by the commonly used clinicopathological parameters.
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