ArticleEJNMMI radiopharmacy and chemistry2019
Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[
Article in EJNMMI radiopharmacy and chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Spatial Distribution of Brain PET Tracers by MALDI Imaging.Journal of the American Society for Mass Spectrometry · 2025Article
- Proof-of-concept optimization of a copper-mediatedLab on a chip · 2023Article
- MGMT promoter methylation status shows no effect on [European radiology · 2022Article
- Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry.Scientific reports · 2022Article
- Economical droplet-based microfluidic production of [Scientific reports · 2021Article
- Optimization of Radiochemical Reactions using Droplet Arrays.Journal of visualized experiments : JoVE · 2021Article
- Highlight selection of radiochemistry and radiopharmacy developments by editorial board (January-June 2020).EJNMMI radiopharmacy and chemistry · 2021Review
- A simple and efficient automated microvolume radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2020Article
- High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress.Molecular imagingReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[ PROCEDURES: The synthesis was carried out in microvolume droplets manipulated on a disposable patterned silicon "chip" affixed to a heater. A droplet of [
resultsThe microdroplet synthesis exhibited an overall decay-corrected radiochemical yield of 55 ± 7% (n = 4) after purification and formulation. When automated, the synthesis could be completed in 35 min. Starting with < 370 MBq of activity, ~ 150 MBq of [
conclusionsA microdroplet synthesis of [
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Registered trials
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