Evidence map›Paper›PMID 31893310›Full record

ArticleCellular and molecular life sciences : CMLS2020

Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism.

Magdalena Losko, Dobrochna Dolicka, Natalia Pydyn, Urszula Jankowska, Sylwia Kedracka-Krok, Maria Kulecka, Agnieszka Paziewska, Michal Mikula, Piotr Major, Marek Winiarski and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  5. Advances in multi-omics study of biomarkers of glycolipid metabolism disorder.Computational and structural biotechnology journal · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Magdalena LoskoDepartment of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.ORCID http://orcid.org/0000-0001-9511-1747
Dobrochna DolickaDepartment of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Natalia PydynDepartment of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Urszula JankowskaProteomics and Mass Spectrometry Laboratory, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387, Kraków, Poland.
Sylwia Kedracka-KrokDepartment of Physical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Maria KuleckaDepartment of Gastroenterology, Hepatology and Clinical Oncology, Medical Center for Postgraduate Education, Marymoncka 99/103, 01-813, Warsaw, Poland.
Agnieszka PaziewskaDepartment of Gastroenterology, Hepatology and Clinical Oncology, Medical Center for Postgraduate Education, Marymoncka 99/103, 01-813, Warsaw, Poland.
Michal MikulaDepartment of Genetics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Wawelska 15B, 02-034, Warsaw, Poland.
Piotr MajorSecond Department of General Surgery, Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Jagiellonian University Medical College, Kopernika 21, 31-501, Kraków, Poland.
Marek WiniarskiSecond Department of General Surgery, Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Jagiellonian University Medical College, Kopernika 21, 31-501, Kraków, Poland.
Andrzej BudzynskiSecond Department of General Surgery, Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Jagiellonian University Medical College, Kopernika 21, 31-501, Kraków, Poland.
Jolanta JuraDepartment of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland. jolanta.jura@uj.edu.pl.ORCID http://orcid.org/0000-0002-0816-3475
Jagiellonian University · PLPostgraduate School of Molecular Medicine · PLThe Maria Sklodowska-Curie National Research Institute of Oncology · PL

Funding

MSHE, Poland BMN7/2016National Science Center, Poland 2013/11/B/NZ2/00125
6 · The paper itself

Abstract

Obesity is considered a serious chronic disease, associated with an increased risk of developing cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes. Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1) is an RNase decreasing stability of transcripts coding for inflammation-related proteins. In addition, MCPIP1 plays an important role in the regulation of adipogenesis in vitro by reducing the expression of key transcription factors, including C/EBPβ. To elucidate the role of MCPIP1 in adipocyte biology, we performed RNA-Seq and proteome analysis in 3T3-L1 adipocytes overexpressing wild-type (

Indexed as

AdipogenesisGenomics3T3-L1 CellsAdipocytesAdultAnimalsCell DifferentiationCytokinesFemaleGlucoseGlucose Transporter Type 4HumansInflammation MediatorsInsulinLipid MetabolismMaleCytokinesGlucoseGlucose Transporter Type 4Inflammation MediatorsInsulinProteomeReceptor, InsulinRibonucleasesRNA, MessengerTranscription FactorsZC3H12A protein, humanZc3h12a protein, mouseC/EBPαLipid homeostasisPparγRegnase-1

Identifiers

PMID31893310
PMCPMC7658075
OpenAlexW2997802586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.