Evidence map›Paper›PMID 31893285›Full record

ArticleUncertainty for safe utilization of machine learning in medical imaging and clinical image-based procedures : first International Workshop, UNSURE 2019, and 8th International Workshop, CLIP 2019, held in conjunction with MICCAI 2019, Sh...2019

Multi-instance Deep Learning with Graph Convolutional Neural Networks for Diagnosis of Kidney Diseases Using Ultrasound Imaging.

Shi Yin, Qinmu Peng, Hongming Li, Zhengqiang Zhang, Xinge You, Hangfan Liu, Katherine Fischer, Susan L Furth, Gregory E Tasian, Yong Fan

Abstract read
In one paragraph

Article in Uncertainty for safe utilization of machine learning in medical imaging and clinical image-based procedures : first International Workshop, UNSURE 2019, and 8th International Workshop, CLIP 2019, held in conjunction with MICCAI 2019, Sh..., 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Geometric Deep Learning for Multimodal Data in CKD.Journal of the American Society of Nephrology : JASN · 2025
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  2. Enhancing Whole Slide Image Classification with Discriminative and Contrastive Learning.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shi YinSchool of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
Qinmu PengSchool of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
Hongming LiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhengqiang ZhangSchool of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
Xinge YouSchool of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
Hangfan LiuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Katherine FischerDepartment of Surgery, Division of Pediatric Nephrology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Susan L FurthDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Gregory E TasianDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yong FanDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Huazhong University of Science and Technology · CNChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Research Project Core 2P50DK114786 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Razzaghi Hanieh · 2017 to 2026
$9.6M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
Anatomic biomarkers of chronic kidney disease progression among childrenR21DK117297 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG, TASIAN, GREGORY EDWARD · 2019 to 2020
$469k
NCATS NIH HHS UL1 TR001878NIDDK NIH HHS P50 DK114786NIDDK NIH HHS R21 DK117297NIH HHS S10 OD023495
6 · The paper itself

Abstract

Ultrasound imaging (US) is commonly used in nephrology for diagnostic studies of the kidneys and lower urinary tract. However, it remains challenging to automate the disease diagnosis based on clinical 2D US images since they provide partial anatomic information of the kidney and the 2D images of the same kidney may have heterogeneous appearance. To overcome this challenge, we develop a novel multi-instance deep learning method to build a robust classifier by treating multiple 2D US images of each individual subject as multiple instances of one bag. Particularly, we adopt convolutional neural networks (CNNs) to learn instance-level features from 2D US kidney images and graph convolutional networks (GCNs) to further optimize the instance-level features by exploring potential correlation among instances of the same bag. We also adopt a gated attention-based MIL pooling to learn bag-level features using full-connected neural networks (FCNs). Finally, we integrate both instance-level and bag-level supervision to further improve the bag-level classification accuracy. Ablation studies and comparison results have demonstrated that our method could accurately diagnose kidney diseases using ultrasound imaging, with better performance than alternative state-of-the-art multi-instance deep learning methods.

Indexed as

Automatic diagnosisGraph convolutional neural networksMulti-instance learningUltrasound imaging

Identifiers

PMID31893285
PMCPMC6938161
OpenAlexW2980259907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.