ArticleACS central science2019
Micrococcal-Nuclease-Triggered On-Demand Release of Vancomycin from Intramedullary Implant Coating Eradicates
Article in ACS central science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Modulating Micrococcal Nuclease-Triggered Antibiotic Releases for One-Stage Revisions ofACS infectious diseases · 2026Article
- Bioengineering methods for tailoring treatment of Osteomyelitis: Advancing strategies and application.Materials today. Bio · 2025Review
- Semiconducting Polymer-Based Nanocomposite for Photothermal Elimination ofMicroorganisms · 2025Article
- Bonding of Hydrogel to Biometal Surfaces: Principles, Methods and Applications.Exploration (Beijing, China) · 2025Review
- Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field.Biomaterials research · 2025Review
- The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Biocompatibility Analysis of the Silver-Coated Microporous Titanium Implants Manufactured with 3D-Printing Technology.Nanomaterials (Basel, Switzerland) · 2024Article
- Triggered Release of Ampicillin from Metallic Implant Coatings for Combating Periprosthetic Infections.ACS applied materials & interfaces · 2024Article
- Injectable Nano-Micro Composites with Anti-bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multifunctionally disordered TiOTheranostics · 2024Article
- Hematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair.Bioactive materials · 2023Article
- Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation.Bioactive materials · 2023Review
- Modulating On-Demand Release of Vancomycin from Implant Coatings via Chemical Modification of a Micrococcal Nuclease-Sensitive Oligonucleotide Linker.ACS applied materials & interfaces · 2023Article
- Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Antibacterial coatings on orthopedic implants.Materials today. Bio · 2023Review
- Flourishing Antibacterial Strategies for Osteomyelitis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Antimicrobial-Loaded Polyacrylamide Hydrogels Supported on Titanium as Reservoir for Local Drug Delivery.Pathogens (Basel, Switzerland) · 2023Article
- Recent Advancements in Metallic Drug-Eluting Implants.Pharmaceutics · 2023Review
- Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties.Theranostics · 2023Article
- Sterilization of Polymeric Implants: Challenges and Opportunities.ACS applied bio materials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Preventing orthopedic implant-associated bacterial infections remains a critical challenge. Current practices of physically blending high-dose antibiotics with bone cements is known for cytotoxicity while covalently tethering antibiotics to implant surfaces is ineffective in eradicating bacteria from the periprosthetic tissue environment due to the short-range bactericidal actions, which are limited to the implant surface. Here, we covalently functionalize poly(ethylene glycol) dimethacrylate hydrogel coatings with vancomycin via an oligonucleotide linker sensitive to
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.