Evidence map›Paper›PMID 31893123›Full record

ArticlePharmacology research & perspectives2020

Characterization of the various functional pathways elicited by synthetic agonists or antagonists at the melatonin MT

Céline Legros, Clémence Dupré, Chantal Brasseur, Anne Bonnaud, Olivier Bruno, Damien Valour, Preety Shabajee, Adeline Giganti, Olivier Nosjean, Terrence P Kenakin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Functionality of Melatonin Receptors: Recruitment of β-Arrestin at MT1.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  9. Detection of Melatonin in Tissue Samples.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  10. Alternative Ligands at Melatonin Receptors.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. Functionality of Melatonin Receptors: Internalization.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  12. MT1 Receptor Signaling Pathways by Impedance Measurement.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  13. Why Are We Still Cloning Melatonin Receptors? A Commentary.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Céline LegrosPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Clémence DupréPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Chantal BrasseurPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Anne BonnaudPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Olivier BrunoPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Damien ValourPôle d'Expetise Méthodologie et Valorisation des Données Institut de Recherches Internationales Servier Suresnes France.
Preety ShabajeePôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Adeline GigantiPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Olivier NosjeanPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.
Terrence P KenakinDepartment of Pharmacology University of North Carolina School of Medicine Chapel Hill NC USA.
Jean A BoutinPôle d'Expertise Biotechnologie Chimie & Biologie Institut de Recherches Servier Croissy-sur-Seine France.ORCID 0000-0003-0068-7204
Servier (France) · FRUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melatonin is a neurohormone that translates the circadian rhythm to the peripheral organs through a series of binding sites identified as G protein-coupled receptors MT

Indexed as

Animalsbeta-ArrestinsCell LineCHO CellsCricetulusCyclic AMPGuanosine 5'-O-(3-Thiotriphosphate)HEK293 CellsHumansMolecular StructureReceptor, Melatonin, MT1Receptor, Melatonin, MT2Signal TransductionSmall Molecule Librariesbeta-ArrestinsCyclic AMPGuanosine 5'-O-(3-Thiotriphosphate)Receptor, Melatonin, MT1Receptor, Melatonin, MT2Small Molecule Librariesbiased ligandsmelatoninmelatonin receptorssignaling pathways

Identifiers

PMID31893123
PMCPMC6935685
OpenAlexW2997640945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.