Evidence map›Paper›PMID 31893041›Full record

SynthesisAntimicrobial resistance and infection control2019

Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis.

Nina Droz, Yingfen Hsia, Sally Ellis, Angela Dramowski, Mike Sharland, Romain Basmaci

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Antimicrobial resistance and infection control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  7. Mechanisms ofBreathe (Sheffield, England) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nina Droz1Service de Pédiatrie-Urgences, Hôpital Louis-Mourier, APHP, 178 rue des Renouillers, 92700 Colombes, France.
Yingfen Hsia2Paediatric Infectious Diseases Research Group, Institute of Infection and Immunity, St George's, University of London, London, UK.
Sally EllisGlobal Antibiotic Research and Development Partnership, Geneva, Switzerland.
Angela Dramowski4Department of Paediatrics and Child Health, Division of Paediatric Infectious Diseases, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Mike Sharland2Paediatric Infectious Diseases Research Group, Institute of Infection and Immunity, St George's, University of London, London, UK.
Romain Basmaci1Service de Pédiatrie-Urgences, Hôpital Louis-Mourier, APHP, 178 rue des Renouillers, 92700 Colombes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite a high mortality rate in childhood, there is limited evidence on the causes and outcomes of paediatric bloodstream infections from low- and middle-income countries (LMICs). We conducted a systematic review and meta-analysis to characterize the bacterial causes of paediatric bloodstream infections in LMICs and their resistance profile. Methods: We searched Pubmed and Embase databases between January 1st 1990 and October 30th 2019, combining MeSH and free-text terms for "sepsis" and "low-middle-income countries" in children. Two reviewers screened articles and performed data extraction to identify studies investigating children (1 month-18 years), with at least one blood culture. The main outcomes of interests were the rate of positive blood cultures, the distribution of bacterial pathogens, the resistance patterns and the case-fatality rate. The proportions obtained from each study were pooled using the Freeman-Tukey double arcsine transformation, and a random-effect meta-analysis model was used. Results: We identified 2403 eligible studies, 17 were included in the final review including 52,915 children (11 in Africa and 6 in Asia). The overall percentage of positive blood culture was 19.1% [95% CI: 12.0-27.5%]; 15.5% [8.4-24.4%] in Africa and 28.0% [13.2-45.8%] in Asia. A total of 4836 bacterial isolates were included in the studies; 2974 were Gram-negative (63.9% [52.2-74.9]) and 1858 were Gram-positive (35.8% [24.9-47.5]). In Asia, Conclusions: We observed a marked variation in pathogen distribution and their resistance profiles between Asia and Africa. Very limited data is available on underlying risk factors for bacteraemia, patterns of treatment of multidrug-resistant infections and predictors of adverse outcomes.

Indexed as

Drug Resistance, BacterialAdolescentAfricaAnti-Bacterial AgentsAsiaBacteremiaBacteriaChildChild HealthChild, PreschoolCommunity-Acquired InfectionsDeveloping CountriesHumansInfantMicrobial Sensitivity TestsObservational Studies as TopicAnti-Bacterial AgentsAntimicrobial resistanceBacteraemiaBloodstream infectionChildrenEpidemiologyResource-limited settingsSepsis

Identifiers

PMID31893041
PMCPMC6937962

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.