Evidence map›Paper›PMID 31893021›Full record

ArticleMolecular autism2019

Increased Ca

Sahar Avazzadeh, Katya McDonagh, Jamie Reilly, Yanqin Wang, Stephanie D Boomkamp, Veronica McInerney, Janusz Krawczyk, Jacqueline Fitzgerald, Niamh Feerick, Matthew O'Sullivan and 11 more

Open access · goldAbstract read
In one paragraph

Article in Molecular autism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Distinct Synaptic Mechanisms DrivebioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Alpha-neurexins in health and disease.Frontiers in molecular neuroscience · 2025
    Review
  13. Antioxidants, Hormetic Nutrition, and Autism.Current neuropharmacology · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 4 countries.

Sahar Avazzadeh1Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, National University of Ireland Galway, Dangan, Upper Newcastle, Galway, Ireland.
Katya McDonagh1Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, National University of Ireland Galway, Dangan, Upper Newcastle, Galway, Ireland.
Jamie Reilly1Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, National University of Ireland Galway, Dangan, Upper Newcastle, Galway, Ireland.
Yanqin Wang1Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, National University of Ireland Galway, Dangan, Upper Newcastle, Galway, Ireland.
Stephanie D Boomkamp1Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, National University of Ireland Galway, Dangan, Upper Newcastle, Galway, Ireland.
Veronica McInerney3HRB Clinical Research Facility, National University of Ireland (NUI), Galway, Ireland.
Janusz Krawczyk4Department of Haematology, Galway University Hospital, Galway, Ireland.
Jacqueline Fitzgerald5School of Medicine, Trinity College Dublin, Dublin, Ireland.
Niamh Feerick5School of Medicine, Trinity College Dublin, Dublin, Ireland.
Matthew O'Sullivan5School of Medicine, Trinity College Dublin, Dublin, Ireland.
Amirhossein Jalali6School of Medicine, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
Eva B Forman7Children's University Hospital, Temple Street, Dublin, Ireland.
Sally A LynchDepartment of Clinical Genetics, OLCHC, Dublin 12, Ireland.
Sean Ennis11UCD Academic Centre on Rare Diseases, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
Nele Cosemans12Centre for Human Genetics, University Hospital Leuven, KU Leuven, 3000 Leuven, Belgium.
Hilde Peeters10Academic Center on Rare Diseases, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
Peter Dockery13Centre for Microscopy and Imaging, Anatomy, School of Medicine, National University of Ireland (NUI), Galway, Ireland.
Timothy O'Brien1Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, National University of Ireland Galway, Dangan, Upper Newcastle, Galway, Ireland.
Leo R Quinlan14Physiology and Human Movement Laboratory, CÚRAM SFI Centre for Research in Medical Devices, School of Medicine, National University of Ireland (NUI), Galway, Ireland.
Louise Gallagher5School of Medicine, Trinity College Dublin, Dublin, Ireland.
Sanbing Shen1Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, National University of Ireland Galway, Dangan, Upper Newcastle, Galway, Ireland.ORCID 0000-0002-8217-9811
Ollscoil na Gaillimhe – University of Galway · IETrinity College Dublin · IEUniversity College Dublin · IENational University of Ireland · IECenter for Human Genetics · USScience Foundation Ireland · IETemple Street Children's University Hospital · IEUniversity Hospital Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high co-morbidity of epilepsy and associated with hundreds of rare risk factors. Methods: Skin biopsies were donated by five healthy donors and three ASD patients carrying Results: Conclusions: This is the first report to show that human

Indexed as

Calcium SignalingAction PotentialsAutism Spectrum DisorderCalcium-Binding ProteinsCalcium ChannelsCell DifferentiationFemaleHumansInduced Pluripotent Stem CellsIon TransportKineticsMaleNeural Cell Adhesion MoleculesNeuronsReproducibility of ResultsCalcium-Binding ProteinsCalcium ChannelsNeural Cell Adhesion MoleculesNRXN1 protein, humanAutismCalcium signalingInduced pluripotent stem cellsNeuronsNRXN1αTranscriptome

Identifiers

PMID31893021
PMCPMC6937972
OpenAlexW2998014962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.