Evidence map›Paper›PMID 31893010›Full record

ArticleBiomicrofluidics2019

Boyden chamber-based compartmentalized tumor spheroid culture system to implement localized anticancer drug treatment.

Shohei Kaneda, Jiro Kawada, Marie Shinohara, Momoko Kumemura, Ryohei Ueno, Tomoaki Kawamoto, Kenji Suzuki, Beomjoon Kim, Yoshiho Ikeuchi, Yasuyuki Sakai and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomicrofluidics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Microfluidics-Based Single-Cell Research for Intercellular Interaction.Frontiers in cell and developmental biology · 2021
    Review
  4. Cell Culture BasedFrontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Shohei KanedaORCID 0000-0003-2369-4132
Jiro KawadaCenter for International Research on Integrative Biomedical Systems, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 156-0041, Japan.
Marie ShinoharaCenter for International Research on Integrative Biomedical Systems, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 156-0041, Japan.
Momoko Kumemura
Ryohei UenoLIMMS-CNRS/IIS, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 156-0041, Japan.
Tomoaki KawamotoDepartment of Mechanical Systems Engineering, Faculty of Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachioji-shi, Tokyo 192-0015, Japan.
Kenji SuzukiDepartment of Mechanical Systems Engineering, Faculty of Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachioji-shi, Tokyo 192-0015, Japan.
Beomjoon KimORCID 0000-0001-9565-299X
Yoshiho IkeuchiORCID 0000-0002-2829-3840
Yasuyuki Sakai
Dominique CollardLIMMS-CNRS/IIS, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 156-0041, Japan.
Hiroyuki FujitaCenter for Interdisciplinary Research on Micro-Nano Methods, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 156-0041, Japan.
Teruo FujiiCenter for International Research on Integrative Biomedical Systems, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 156-0041, Japan.
The University of Tokyo · JPLaboratory for Integrated Micro-Mechatronic Systems · JPKogakuin University · JPTokyo Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In anticancer drug development, it is important to simultaneously evaluate both the effect of drugs on cell proliferation and their ability to penetrate tissues. To realize such an evaluation process, here, we present a compartmentalized tumor spheroid culture system utilizing a thin membrane with a through-hole to conduct localized anticancer treatment of tumor spheroids and monitor spheroid dimensions as an indicator of cell proliferation. The system is based on a commercialized Boyden chamber plate; a through-hole was bored through a porous membrane of the chamber, and the pre-existing 0.4

Identifiers

PMID31893010
PMCPMC6932857
OpenAlexW2982089680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.