ArticleSensors and actuators. B, Chemical1999
Intensity measurements in scattering media.
Article in Sensors and actuators. B, Chemical, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- On the Possibility of Glucose Sensing Using Boronic Acid and a Luminescent Ruthenium Metal-Ligand Complex.Journal of fluorescence · 2002Article
- Novel fluorescence sensing methods for high throughput screening.Journal of biomolecular screening · 2000Article
- Polarization-based sensing of glucose using an oriented reference film.Journal of biomedical optics · 1999Article
- Polarization sensing with visual detection.Analytical chemistry · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We describe a new method which allows quantitative measurements of fluorescence intensity in highly scattering media. The measurement principle is based on observing the emission from both the fluorophore of interest with a nanosecond decay time and of a reference fluorophore which displays a much longer microsecond lifetime. The reference fluorophore is placed on rather than in the sample to mimic a sensing device with the long lifetime reference held against the skin. The amplitude modulation of the emission is observed using the standard method of frequency-domain (FD) fluorometry. At an intermediate modulation frequency, the modulation is equivalent to the fractional intensity of the nanosecond fluorophore. The method was tested in 0.5% intralipid, which is more highly scattering than skin. Quantitative intensity measurements were obtained for various concentrations of fluorescein in intralipid, and of the pH sensor 6-carboxyfluorescein (6-CF). Low frequency modulation measurements provide a general method for quantitative measurements in the presence of factors which preclude direct intensity measurements.
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Registered trials
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