Evidence map›Paper›PMID 31892764›Full record

ArticleInverse problems2018

Deconvolving the input to random abstract parabolic systems: a population model-based approach to estimating blood/breath alcohol concentration from transdermal alcohol biosensor data.

Melike Sirlanci, I G Rosen, Susan E Luczak, Catharine E Fairbairn, Konrad Bresin, Dahyeon Kang

Registry-linked trialAbstract read
In one paragraph

Article in Inverse problems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05692830 (Towards a Wearable Alcohol Biosensor), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05692830 recruitingnot on this mapstarted 2022, after this paper: background citation

Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms

TypeobservationalSponsorUniversity of Illinois at Urbana-ChampaignRan2022 to 2027Enrolled240ConditionsAlcohol Drinking, Alcohol IntoxicationArmsAlcohol
3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  15. Estimating the Distribution of Random Parameters in a Diffusion Equation Forward Model for a Transdermal Alcohol Biosensor.Automatica : the journal of IFAC, the International Federation of Automatic Control · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melike SirlanciDepartment of Mathematics, University of Southern California.
I G RosenDepartment of Mathematics, University of Southern California.
Susan E LuczakDepartment of Psychology, University of Southern California.
Catharine E FairbairnDepartment of Psychology, University of Illinois Urbana-Champaign.
Konrad BresinDepartment of Psychology, University of Illinois Urbana-Champaign.
Dahyeon KangDepartment of Psychology, University of Illinois Urbana-Champaign.

Funding

Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory MethodsR01AA025969 · NIAAA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Catharine Fairbairn · 2017 to 2026
$3.5M
Estimating BrAC/BAC from Transdermal Alcohol: Combining First-Principles Physiological Models with Machine-Learning to Create Software to Optimally Process and Quantitatively Interpret Biosensor DataR01AA026368 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUCZAK, SUSAN E, ROSEN, GARY · 2018 to 2022
$2.8M
Real-Time Assessment of Alcohol Use Across ALDH2 GenotypesR21AA017711 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUCZAK, SUSAN E · 2009 to 2010
$410k
NIAAA NIH HHS R01 AA025969NIAAA NIH HHS R01 AA026368NIAAA NIH HHS R21 AA017711
6 · The paper itself

Abstract

The distribution of random parameters in, and the input signal to, a distributed parameter model with unbounded input and output operators for the transdermal transport of ethanol are estimated. The model takes the form of a diffusion equation with the input, which is on the boundary of the domain, being the blood or breath alcohol concentration (BAC/BrAC), and the output, also on the boundary, being the transdermal alcohol concentration (TAC). Our approach is based on the reformulation of the underlying dynamical system in such a way that the random parameters are treated as additional spatial variables. When the distribution to be estimated is assumed to be defined in terms of a joint density, estimating the distribution is equivalent to estimating a functional diffusivity in a multi-dimensional diffusion equation. The resulting system is referred to as a population model, and well-established finite dimensional approximation schemes, functional analytic based convergence arguments, optimization techniques, and computational methods can be used to fit it to population data and to analyze the resulting fit. Once the forward population model has been identified or trained based on a sample from the population, the resulting distribution can then be used to deconvolve the BAC/BrAC input signal from the biosensor observed TAC output signal formulated as either a quadratic programming or linear quadratic tracking problem. In addition, our approach allows for the direct computation of corresponding credible bands without simulation. We use our technique to estimate bivariate normal distributions and deconvolve BAC/BrAC from TAC based on data from a population that consists of multiple drinking episodes from a single subject and a population consisting of single drinking episodes from multiple subjects.

Indexed as

DeconvolutionDistributed parameter systemsLinear semigroups of operatorsPopulation modelRandom abstract parabolic systemsSystem identificationTransdermal alcohol biosensor

Identifiers

PMID31892764
PMCPMC6938217

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.