ArticleScientific reports2019
Intraoperative assessment of skull base tumors using stimulated Raman scattering microscopy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Fact-finding with fungi: A scoping review on recent advancements in the role of fungi as evidence in forensic science.International journal of legal medicine · 2026Article
- Mode-Specific Coherent Interference of Vibrational Sum-Frequency Generation Imaging: An Approach to Differentiate Lung Tumors through Collagen Interfibrillar Distances.Journal of the American Chemical Society · 2025Article
- Artificial Intelligence-Assisted Stimulated Raman Histology: New Frontiers in Vibrational Tissue Imaging.Cancers · 2024Review
- Label-free optical imaging for brain cancer assessment.Trends in cancer · 2024Review
- Virtual Staining of Nonfixed Tissue Histology.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Review
- Seeing is Believing: Developing Multimodal Metabolic Insights at the Molecular Level.ACS central science · 2024Review
- Virtual formalin-fixed and paraffin-embedded staining of fresh brain tissue via stimulated Raman CycleGAN model.Science advances · 2024Article
- Recent Advances in Enhancement of Raman Scattering Intensity for Biological Applications.Chemical & biomedical imaging · 2023Review
- Rapid digital pathology of H&E-stained fresh human brain specimens as an alternative to frozen biopsy.Communications medicine · 2023Article
- Surgical margin assessment of bone tumours: A systematic review of current and emerging technologies.Journal of bone oncology · 2023Review
- Stimulated Raman Scattering Microscopy Enables Gleason Scoring of Prostate Core Needle Biopsy by a Convolutional Neural Network.Cancer research · 2023Article
- Meningiomas with CNS invasion.Frontiers in neuroscience · 2023Review
- Stimulated Raman Histology for Rapid Intra-Operative Diagnosis of Sinonasal and Skull Base Tumors.The Laryngoscope · 2022Article
- Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology.Nature communications · 2022Article
- Quantitative Stimulated Raman Scattering Microscopy: Promises and Pitfalls.Annual review of analytical chemistry (Palo Alto, Calif.) · 2022Review
- In vivo simultaneous nonlinear absorption Raman and fluorescence (SNARF) imaging of mouse brain cortical structures.Communications biology · 2022Article
- Quantitative Chemical Imaging of Bone Tissue for Intraoperative and Diagnostic Applications.Analytical chemistry · 2022Article
- Real-Time, Two-Color Stimulated Raman Scattering Imaging of Mouse Brain for Tissue Diagnosis.Journal of visualized experiments : JoVE · 2022Article
- From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives.Free neuropathology · 2022Article
- Raman Scattering-Based Biosensing: New Prospects and Opportunities.Biosensors · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Intraoperative consultations, used to guide tumor resection, can present histopathological findings that are challenging to interpret due to artefacts from tissue cryosectioning and conventional staining. Stimulated Raman histology (SRH), a label-free imaging technique for unprocessed biospecimens, has demonstrated promise in a limited subset of tumors. Here, we target unexplored skull base tumors using a fast simultaneous two-channel stimulated Raman scattering (SRS) imaging technique and a new pseudo-hematoxylin and eosin (H&E) recoloring methodology. To quantitatively evaluate the efficacy of our approach, we use modularized assessment of diagnostic accuracy beyond cancer/non-cancer determination and neuropathologist confidence for SRH images contrasted to H&E-stained frozen and formalin-fixed paraffin-embedded (FFPE) tissue sections. Our results reveal that SRH is effective for establishing a diagnosis using fresh tissue in most cases with 87% accuracy relative to H&E-stained FFPE sections. Further analysis of discrepant case interpretation suggests that pseudo-H&E recoloring underutilizes the rich chemical information offered by SRS imaging, and an improved diagnosis can be achieved if full SRS information is used. In summary, our findings show that pseudo-H&E recolored SRS images in combination with lipid and protein chemical information can maximize the use of SRS during intraoperative pathologic consultation with implications for tissue preservation and augmented diagnostic utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.