Evidence map›Paper›PMID 31892657›Full record

ArticleBMJ open2019

Improving mental health and physiological stress responses in mothers following traumatic childbirth and in their infants: study protocol for the Swiss TrAumatic biRth Trial (START).

Vania Sandoz, Camille Deforges, Suzannah Stuijfzand, Manuella Epiney, Yvan Vial, Nicole Sekarski, Nadine Messerli-Bürgy, Ulrike Ehlert, Myriam Bickle-Graz, Mathilde Morisod Harari and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03576586 (Improving Mental Health and Physiological Stress Responses in Mothers Following Traumatic Childbirth and in Their Infants), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03576586 nacompletednot on this map

Improving Mental Health and Physiological Stress Responses in Mothers Following Traumatic Childbirth and in Their Infants: a Randomised Controlled Trial (START)

TypeinterventionalSponsorCentre Hospitalier Universitaire VaudoisRan2018 to 2022Enrolled147ConditionsPosttraumatic Stress Disorder, Acute Stress DisorderArmsBrief computerized intervention, Attention placebo control
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Vania SandozInstitute of Higher Education and Research in Healthcare-IUFRS, University of Lausanne and Lausanne University Hospital, Lausanne, VD, Switzerland.ORCID 0000-0002-2763-667X
Camille DeforgesInstitute of Higher Education and Research in Healthcare-IUFRS, University of Lausanne and Lausanne University Hospital, Lausanne, VD, Switzerland.
Suzannah StuijfzandInstitute of Higher Education and Research in Healthcare-IUFRS, University of Lausanne and Lausanne University Hospital, Lausanne, VD, Switzerland.
Manuella EpineyDepartment Woman-Child-Adolescent, Geneva University Hospital and University of Geneva, Geneva, GE, Switzerland.
Yvan VialObstetrics and Gynecology Service, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, VD, Switzerland.
Nicole SekarskiPaediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, VD, Switzerland.
Nadine Messerli-BürgyClinical Child Psychology & Biological Psychology, University of Fribourg, Fribourg, FR, Switzerland.
Ulrike EhlertDepartment of Clinical Psychology and Psychotherapy, University of Zurich, Zurich, ZH, Switzerland.
Myriam Bickle-GrazNeonatology Service, Woman-Mother-Child Department, University of Lausanne and Lausanne University Hospital, Lausanne, VD, Switzerland.
Mathilde Morisod HarariService of Child and Adolescent Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, VD, Switzerland.
Kate PorcheretTurner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Daniel S SchechterService of Child and Adolescent Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, VD, Switzerland.
Susan AyersCentre for Maternal and Child Health Research, School of Health Sciences, City University of London, London, London, UK.
Emily A HolmesDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Antje HorschInstitute of Higher Education and Research in Healthcare-IUFRS, University of Lausanne and Lausanne University Hospital, Lausanne, VD, Switzerland antje.horsch@chuv.ch.
START Research Consortium
University of Lausanne · CHUniversity of Geneva · CHCity, University of London · GBMonash University · AUUniversity of Fribourg · CHUniversity of Zurich · CHUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEmergency caesarean section (ECS) qualifies as a psychological trauma, which may result in postnatal post-traumatic stress disorder (PTSD). Maternal PTSD may not only have a significant negative impact on mother-infant interactions, but also on long-term infant development. The partner's mental health may also affect infant development. Evidence-based early interventions to prevent the development of postpartum PTSD in mothers are lacking. Immediately after a traumatic event, memory formation is vulnerable to interference. There is accumulating evidence that a brief behavioural intervention including a visuospatial task may result in a reduction in intrusive memories of the trauma. METHODS AND ANALYSIS: This study protocol describes a double-blind multicentre randomised controlled phase III trial testing an early brief maternal intervention including the computer game 'Tetris' on intrusive memories of the ECS trauma (≤1 week) and PTSD symptoms (6 weeks, primary outcome) of 144 women following an ECS. The intervention group will carry out a brief behavioural procedure including playing Tetris. The attention-placebo control group will complete a brief written activity log. Both simple cognitive tasks will be completed within the first 6 hours following traumatic childbirth. The intervention is delivered by midwives/nurses in the maternity unit.The primary outcome will be differences in the presence and severity of maternal PTSD symptoms between the intervention and the attention-placebo control group at 6 weeks post partum. Secondary outcomes will be physiological stress and psychological vulnerability, mother-infant interaction and infant developmental outcomes. Other outcomes will be psychological vulnerability and physiological regulation of the partner and their bonding with the infant, as well as the number of intrusive memories of the event. ETHICS AND DISSEMINATION: Ethical approval was granted by the Human Research Ethics Committee of the Canton de Vaud (study number 2017-02142). Dissemination of results will occur via national and international conferences, in peer-reviewed journals, public conferences and social media. TRIAL REGISTRATION NUMBER: NCT03576586.

Indexed as

Cesarean SectionStress Disorders, Post-TraumaticChild DevelopmentClinical Trials, Phase III as TopicCrisis InterventionDouble-Blind MethodEarly Medical InterventionEmergenciesFemaleHumansInfantMental HealthMother-Child RelationsOutcome Assessment, Health CarePregnancyRandomized Controlled Trials as Topiccortisolearly interventionHRVinfant developmentmaternal mental healthPTSD

Identifiers

PMID31892657
PMCPMC6955544
OpenAlexW2997618965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.