Evidence map›Paper›PMID 31892550›Full record

ArticleAnticancer research2020

Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.

Muneer Abbas, Tshela Mason, Aliza Ibad, Mozna Khraiwesh, Victor Apprey, Yasmine Kanaan, Bradford Wilson, Georgia Dunston, Luisel Ricks-Santi, Hassan Brim

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anticancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Association of theGenetics research · 2022
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Muneer AbbasDepartment of Microbiology, Howard University, Washington, DC, U.S.A. m_abbas@howard.edu.
Tshela MasonThe National Human Genome Center, Howard University, Washington, DC, U.S.A.
Aliza IbadThe National Human Genome Center, Howard University, Washington, DC, U.S.A.
Mozna KhraiweshExperimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, U.S.A.
Victor AppreyThe National Human Genome Center, Howard University, Washington, DC, U.S.A.
Yasmine KanaanDepartment of Microbiology, Howard University, Washington, DC, U.S.A.
Bradford WilsonThe National Human Genome Center, Howard University, Washington, DC, U.S.A.
Georgia DunstonDepartment of Microbiology, Howard University, Washington, DC, U.S.A.
Luisel Ricks-SantiCancer Research Center, Hampton University, Hampton, VA, U.S.A.
Hassan BrimDepartment of Pathology, Howard University College of Medicine, Washington, DC, U.S.A.
Howard University · USHampton University · USWalter Reed Army Institute of Research · US

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI Tatiana V.D. Sanses · 2019 to 2026
$37.7M
STRUCTURAL/FUNCTIONAL CHARACTERIZATION OF AMINOGLYCOSIDEG12RR003048 · NCRR · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 1985 to 2011
$19.0M
The Howard University SCORE Program Supplemental GrantS06GM008016 · NIGMS · HOWARD UNIVERSITY · PI LITTLETON, GEORGE K · 1989 to 2009
$16.1M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
NCRR NIH HHS G12 RR003048NIGMS NIH HHS S06 GM008016NIMHD NIH HHS G12 MD007597NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

BACKGROUND/

aimEven though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking. MATERIALS AND

methodsA total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data.

resultsrs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer.

conclusionIL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression.

Indexed as

Polymorphism, Single NucleotidePromoter Regions, GeneticAgedAllelesBiomarkersBlack or African AmericanCase-Control StudiesDisease SusceptibilityGenotypeHaplotypesHumansInterleukin-10MaleMiddle AgedNeoplasm GradingProstatic NeoplasmsBiomarkersIL10 protein, humanInterleukin-10African-Americaninflammationinterleukin 10prostate cancerSingle nucleotide polymorphismssmoking

Identifiers

PMID31892550
PMCPMC7731238
OpenAlexW2997378188

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.