ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Regulation of Craving and Negative Emotion in Alcohol Use Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Cognitive reappraisal of food craving and emotions: a coordinate-based meta-analysis of fMRI studies.Social cognitive and affective neuroscience · 2024Pooled it
- Association of Drug Cues and Craving With Drug Use and Relapse: A Systematic Review and Meta-analysis.JAMA psychiatry · 2022Pooled it
- Anger and substance abuse: a systematic review and meta-analysis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Effects of COMT Suppression in a Randomized Trial on the Neural Correlates of Inhibitory Processing Among People With Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Trial
- Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial.Psychopharmacology · 2025Trial
- Effects of transcranial direct current stimulation of the right dorsolateral prefrontal cortex on craving and negative emotion regulation in individuals at risk for problematic pornography use: A double-blind, placebo-controlled study.Journal of behavioral addictions · 2025Trial
- Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study.Scientific reports · 2024Trial
- Effects of Hyperdirect Pathway Theta Burst Transcranial Magnetic Stimulation on Inhibitory Control, Craving, and Smoking in Adults With Nicotine Dependence: A Double-Blind, Randomized Crossover Trial.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Trial
- Randomized trial of mindfulness- and reappraisal-based regulation of craving training among daily cigarette smokers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Trial
- Emotion regulation strategies moderate the impact of negative affect induction on alcohol craving in college drinkers: an experimental paradigm.Journal of American college health : J of ACH · 2023Trial
- Effects of Acute Exercise on Affect, Anxiety, and Self-Esteem in Poly-Substance Dependent Inpatients.European addiction research · 2023Trial
- Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula-bed nucleus of the stria terminalis resting-state functional connectivity.Alcoholism, clinical and experimental research · 2021Trial
- Regulation of Craving: Neural Correlates and the Role of Stress and Delay Discounting.Addiction biology · 2026Article
- Perceived Social Support Moderates the Response to Stress and Alcohol Cues During Early Abstinence From Alcohol.Biological psychiatry global open science · 2026Article
- Craving mediates the association between affect and substance use in daily life among individuals with substance use disorders.Drug and alcohol dependence reports · 2026Article
- Dopamine D2 and GABA(A) Receptors Differentially Regulate Ethanol-Induced Aversion and Reward Through Corticolimbic Circuits.International journal of molecular sciences · 2026Article
- Cue labeling reduces cigarette craving and associated neural activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Dual Role of LH-GABA Neurons in Encoding Alcohol Reward and Aversive Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Tragedy of Errors: The State of Psychedelic Research in the Treatment of Alcohol Use Disorder.Brain sciences · 2025Review
- Pain disparities among Medicaid beneficiaries with chronic low back pain: The differential role of psychological distress.The journal of pain · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlcohol use disorder (AUD) is a chronic, relapsing condition with poor treatment outcomes. Both alcohol craving and negative affect increase alcohol drinking, and-in healthy adults-can be attenuated using cognitive strategies, which rely on the prefrontal cortex (PFC). However, AUD is associated with cognitive impairments and PFC disruptions. Thus, we tested whether individuals with AUD can successfully recruit the PFC to effectively regulate craving and negative emotions, whether neural mechanisms are shared between the two types of regulation, and whether individual differences influence regulation success.
methodsDuring functional magnetic resonance imaging, participants with AUD completed the regulation of craving task (n = 17) that compares a cue-induced craving condition with an instructed regulation condition. They also completed the emotion regulation task (n = 15) that compares a negative affect condition with an instructed regulation condition. Regulation strategies were drawn from cognitive behavioral therapy treatments for AUD. Self-reported craving and negative affect were collected on each trial.
resultsIndividuals with AUD effectively regulated their craving and negative affect when instructed to do so using cognitive behavioral therapy-based strategies. Regulation was associated with recruitment of both common and distinct PFC regions across tasks, as well as with reduced activity in regions associated with craving and negative affect (e.g., ventral striatum, amygdala). Effective regulation of craving was associated with negative alcohol expectancies.
conclusionsBoth common and distinct regulatory systems underlie regulation of craving and negative emotions in AUD, with notable individual differences. This has important implications for AUD treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.