Evidence map›Paper›PMID 31892306›Full record

Observational studyBMC gastroenterology2019

Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.

Kaku So-Armah, Matthew Freiberg, Debbie Cheng, Joseph K Lim, Natalia Gnatienko, Gregory Patts, Margaret Doyle, Daniel Fuster, Dmitry Lioznov, Evgeny Krupitsky and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Role of cellular senescence in hepatic diseases (Review).International journal of molecular medicine · 2025
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Kaku So-ArmahDepartment of Medicine, Boston University School of Medicine, 801 Massachusetts Avenue, Crosstown Building, 2nd Floor, Boston, MA, 02118, USA. kaku@bu.edu.ORCID http://orcid.org/0000-0003-1505-6384
Matthew FreibergDepartment of Medicine, Vanderbilt University School of Medicine; Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA. matthew.s.freiberg@vanderbilt.edu.
Debbie ChengDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Joseph K LimDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Natalia GnatienkoDepartment of Medicine, Boston Medical Center, Boston, MA, USA.
Gregory PattsDepartment of Biostatistics and Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
Margaret DoyleDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Daniel FusterDepartment of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Dmitry LioznovDepartment of Infectious Diseases and Epidemiology, Smorodintsev Research Institute of Influenza, First Pavlov State Medical University, St. Petersburg, Russia.
Evgeny KrupitskyFirst Pavlov State Medical University, V. M. Bekhterev National Research Medical Center for Psychiatry and Neurology, St. Petersburg, Russia.
Jeffrey SametDepartment of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Boston University · USFirst Pavlov State Medical University of St. Petersburg · RUBoston Medical Center · USUniversitat Autònoma de Barcelona · ESUniversity of Vermont · USVanderbilt University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
6 · The paper itself

Abstract

backgroundThe multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, may be accentuated in HIV and leads to poor outcomes. The liver regulates innate immunity and adaptive immune tolerance. HIV-infected people have high prevalence of liver-related comorbidities. We hypothesize that advanced liver fibrosis/cirrhosis is associated with alterations in T-cell subsets consistent with immunosenescence.

methodsART-naïve people with HIV with a recent history of heavy drinking were recruited into a clinical trial of zinc supplementation. Flow cytometry was used to characterize T-cell subsets. The two primary dependent variables were CD8+ and CD4+ T-cells expressing CD28-CD57+ (senescent cell phenotype). Secondary dependent variables were CD8+ and CD4+ T-cells expressing CD45RO + CD45RA- (memory phenotype), CD45RO-CD45RA+ (naïve phenotype), and the naïve phenotype to memory phenotype T-cell ratio (lower ratios associated with immunosenescence). Advanced liver fibrosis/cirrhosis was defined as FIB-4 > 3.25, APRI≥1.5, or Fibroscan measurement ≥10.5 kPa. Analyses were conducted using multiple linear regression adjusted for potential confounders.

resultsMean age was 34 years; 25% female; 88% hepatitis C. Those with advanced liver fibrosis/cirrhosis (N = 25) had higher HIV-1 RNA and more hepatitis C. Advanced liver fibrosis/cirrhosis was not significantly associated with primary or secondary outcomes in adjusted analyses.

conclusionsAdvanced liver fibrosis/cirrhosis was not significantly associated with these senescent T-cell phenotypes in this exploratory study of recent drinkers with HIV. Future studies should assess whether liver fibrosis among those with HIV viral suppression and more advanced, longstanding liver disease is associated with changes in these and other potentially senescent T-cell subsets.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesImmunosenescenceAdultAlcoholismCD28 AntigensCD57 AntigensCross-Sectional StudiesFemaleHepatitis CHIV InfectionsHumansImmunologic MemoryLeukocyte Common AntigensLinear ModelsLiver Cirrhosis, AlcoholicCD28 AntigensCD57 AntigensLeukocyte Common AntigensZincAlcoholHIVImmune senescenceLiver fibrosisRussia

Identifiers

PMID31892306
PMCPMC6938606
OpenAlexW3004285485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.