ArticleBMC gastroenterology2019
Validation of serrated polyps (SPs) in Swedish pathology registers.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Target Trial Emulation of Beta-Blockers After Diagnosis of Colorectal Polyps-Beneficial in Women.United European gastroenterology journal · 2025Article
- Cohort Update: ESPRESSO (Epidemiology Strengthened by Histopathology Reports in Sweden).Clinical epidemiology · 2025Article
- The validity of pathology codes for biopsy-confirmed kidney disease in the Danish National Patobank.Clinical kidney journal · 2024Article
- Inflammatory Bowel Disease and Risk of Colorectal Polyps: A Nationwide Population-Based Cohort Study From Sweden.Journal of Crohn's & colitis · 2023Article
- Target trial emulation of aspirin after diagnosis of colorectal polyps.European journal of epidemiology · 2023Article
- Uncommon causes of acute appendicitis: Retrospective analysis of 6785 histopathological findings in a tertiary center.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Diagnostic yield of endoscopy in irritable bowel syndrome: A nationwide prevalence study 1987-2016.European journal of internal medicine · 2021Article
- Antibiotic Use Associated With Risk of Colorectal Polyps in a Nationwide Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden.BMJ (Clinical research ed.) · 2021Article
- Risk of colorectal cancer incidence and mortality after polypectomy: a Swedish record-linkage study.The lancet. Gastroenterology & hepatology · 2020Article
- A Novel Method for Quantifying Intestinal Inflammatory Burden in Inflammatory Bowel Disease Using Register Data.Clinical epidemiology · 2020Article
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the natural history of serrated polyps (SPs), partly due to the lack of large-scale epidemiologic data. In this study, we examined the validity of SP identification according to SNOMED (Systematised Nomenclature of Medicine) codes and free text from colorectal histopathology reports.
methodsThrough the ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) study, we retrieved data on SPs from all pathology departments in Sweden in 2015-2017 by using SNOMED codes and free-text search in colorectal histopathology reports. Randomly selected individuals with a histopathology report of SPs were validated against patient charts using a structured, retrospective review.
resultsSPs were confirmed in 101/106 individuals with a histopathology report of SPs, yielding a positive predictive value (PPV) of 95% (95%CI = 89-98%). By year of diagnosis, the PPV was 89% (95%CI = 69-97%), 96% (95%CI = 81-99%) and 97% (95%CI = 89-99%) for individuals diagnosed before 2001 (n = 19), between 2001 and 2010 (n = 26) and after 2010 (n = 61), respectively. According to search method, the PPV for individuals identified by SNOMED codes was 100% (95%CI = 93-100%), and 93% (95%CI = 86-97%) using free-text search. Recorded location (colon vs. rectum) was correct in 94% of all SP histopathology reports (95%CI = 84-98%) identified by SNOMED codes. Individuals with SPs were classified into hyperplastic polyps (n = 34; 32%), traditional serrated adenomas (n = 3; 3%), sessile serrated adenomas/polyps (SSA/Ps) (n = 70; 66%), unspecified SPs (n = 3, 3%), and false positive SPs (n = 5, 5%). For individuals identified by SNOMED codes, SSA/Ps were confirmed in 49/52 individuals, resulting in a PPV of 94% (95%CI: 84-98%). In total, 57% had ≥2 polyps (1: n = 44, 2-3: n = 33 and ≥ 4: n = 27). Some 46% of SPs (n = 71) originated from the proximal colon and 24% were ≥ 10 mm in size (n = 37). Heredity for colorectal cancer, intestinal polyposis syndromes, or both was reported in seven individuals (7%). Common comorbidities included diverticulosis (n = 45, 42%), colorectal cancer (n = 19, 18%), and inflammatory bowel disease (n = 10, 9%).
conclusionColorectal histopathology reports are a reliable data source to identify individuals with SPs.
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