Evidence map›Paper›PMID 31892201›Full record

ArticleJournal of clinical medicine2019

A Translational Study of TNF-Alpha Antagonists as an Adjunctive Therapy for Preventing Hemophilic Arthropathy.

Feixu Zhang, Mengyang Xu, Qin Yang, Baolai Hua, Binglan Xia, Zhenyang Lin, Xiao Xiao, Paul E Monahan, Junjiang Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Serum TNF-BioMed research international · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Feixu ZhangSchool of Bioengineering, East China University of Science and Technology, Shanghai‎ 200237, China.
Mengyang XuDepartment of Hematology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China.
Qin YangDepartment of Hematology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China.
Baolai HuaDepartment of Hematology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China.
Binglan XiaDepartment of Hematology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China.
Zhenyang LinSchool of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Xiao XiaoSchool of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Paul E MonahanGene Therapy Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-2110-0740
Junjiang SunGene Therapy Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-7408-0731
Yangzhou University · CNEast China University of Science and Technology · CNUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeated intra-articular hemorrhages lead to hemophilic arthropathy in severe hemophilia. Inflammation and pro-inflammatory cytokines (e.g., tumor necrosis factor alpha (TNFα)) might be involved in this pathogenesis. We hypothesized that anti-TNFα may provide adjuvant protection for hemophilic arthropathy management. We measured TNFα in synovial lavage from hemophilia mice subjected to hemarthrosis induction and synovial fluid from patients with hemophilic arthropathy (

Indexed as

anti-TNFαhemarthrosishemophiliahemophilic arthropathyTNFα

Identifiers

PMID31892201
PMCPMC7019955
OpenAlexW2998050834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.