ArticleInternational journal of molecular sciences2019
Enhanced Osseointegration Capability of Poly(ether ether ketone) via Combined Phosphate and Calcium Surface-Functionalization.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- PEEK in modern maxillofacial surgery: clinical applications, limitations and future opportunities.British dental journal · 2026Review
- Surface Functionalization of Polyetheretherketone With Immobilized γ-Polyglutamic Acid for Enhanced Apatite Formation.ChemistryOpen · 2026Article
- Review
- Influence of PEEK surface modification with titanium for improving osseointegration: an in vitro study.Scientific reports · 2025Article
- Multi-Scale Characterisation and Mechanical Adhesion in PVD-Deposited Ca-SZ Coating for Implantable Medical Devices.Biomedicines · 2024Article
- Flame-Retardant Behavior and Nanocrystal Synthesis through Formation of Multilayers of Poly(acrylic acid) and Zinc Phosphate on Cotton Fabric.ACS omega · 2024Article
- Enhanced human periodontal ligament stem cell viability and osteogenic differentiation on two implant materials: An experimentalF1000Research · 2023Article
- Fabrication ofFrontiers in bioengineering and biotechnology · 2022Article
- Review on Development and Dental Applications of Polyetheretherketone-Based Biomaterials and Restorations.Materials (Basel, Switzerland) · 2021Review
- Dental Pulp Stem Cells on Implant Surface: An In Vitro Study.BioMed research international · 2021Article
- Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Biomedical applications of poly(ether ether ketone) (PEEK) are hindered by its inherent bioinertness and lack of osseointegration capability. In the present study, to enhance osteogenic activity and, hence, the osseointegration capability of PEEK, we proposed a strategy of combined phosphate and calcium surface-functionalization, in which ozone-gas treatment and wet chemistry were used for introduction of hydroxyl groups and modification of phosphate and/or calcium, respectively. Surface functionalization significantly elevated the surface hydrophilicity without changing the surface roughness or topography. The cell study demonstrated that immobilization of phosphate or calcium increased the osteogenesis of rat mesenchymal stem cells compared with bare PEEK, including cell proliferation, alkaline phosphatase activity, and bone-like nodule formation. Interestingly, further enhancement was observed for samples co-immobilized with phosphate and calcium. Furthermore, in the animal study, phosphate and calcium co-functionalized PEEK demonstrated significantly enhanced osseointegration, as revealed by a greater direct bone-to-implant contact ratio and bond strength between the bone and implant than unfunctionalized and phosphate-functionalized PEEK, which paves the way for the orthopedic and dental application of PEEK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.