Evidence map›Paper›PMID 31892063›Full record

ArticleTalanta2020

Database of free solution mobilities for 276 metabolites.

Alexander P Petrov, Lindy M Sherman, Jon P Camden, Norman J Dovichi

Open access · greenAbstract read
In one paragraph

Article in Talanta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. [Annual review of capillary electrophoresis technology in 2020].Se pu = Chinese journal of chromatography · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexander P PetrovDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556-5670, USA.
Lindy M ShermanDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556-5670, USA.
Jon P CamdenDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556-5670, USA.
Norman J DovichiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556-5670, USA. Electronic address: ndovichi@nd.edu.
University of Notre Dame · US

Funding

Technology for single cell proteomics and its application to the analysis of single Xenopus blastomeresR01GM096767 · NIGMS · UNIVERSITY OF NOTRE DAME · PI DOVICHI, NORMAN J · 2011 to 2019
$2.5M
Quantitative proteomics of Xenopus oocytes, eggs, blastomeres, and nuclear transplantsR01HD084399 · NICHD · UNIVERSITY OF NOTRE DAME · PI DOVICHI, NORMAN J · 2015 to 2019
$1.6M
NICHD NIH HHS R01 HD084399NIGMS NIH HHS R01 GM096767
6 · The paper itself

Abstract

Although databases are available that provide mass spectra and chromatographic retention information for small-molecule metabolites, no publicly available database provides electrophoretic mobility for common metabolites. As a result, most compounds found in electrophoretic-based metabolic studies are unidentified and simply annotated as "features". To begin to address this issue, we analyzed 460 metabolites from a commercial library using capillary zone electrophoresis coupled with electrospray mass spectrometry. To speed analysis, a sequential injection method was used wherein six compounds were analyzed per run. An uncoated fused silica capillary was used for the analysis at 20 °C with a 0.5% (v/v) formic acid and 5% (v/v) methanol background electrolyte. A Prince autosampler was used for sample injection and the capillary was coupled to an ion trap mass spectrometer using an electrokinetically-pumped nanospray interface. We generated mobility values for 276 metabolites from the library (60% success rate) with an average standard deviation of 0.01 × 10

Indexed as

Databases, FactualElectrophoresis, CapillaryHumansMetabolomeMetabolomicsSpectrometry, Mass, Electrospray IonizationCapillary electrophoresisMetabolite databaseSequential injection

Identifiers

PMID31892063
PMCPMC6956853
OpenAlexW2988649886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.