ArticleBehavioural brain research2020
Differential effects of prior stress on conditioned inhibition of fear and fear extinction.
Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Neurobiological correlates of behavioral resilience to chronic alcohol and acute stress in male and female rats.Translational psychiatry · 2026Article
- Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning.Psychopharmacology · 2026Article
- Second-order conditioning of safety in male and female rats.Behavioural brain research · 2026Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Article
- Conditioned inhibition of fear and reward in male and female rats.Neurobiology of learning and memory · 2024Article
- Suppressing fear in the presence of a safety cue requires infralimbic cortical signaling to central amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Psychological and physiological correlates of stimulus discrimination in adults.Psychophysiology · 2023Article
- Encoding of conditioned inhibitors of fear in the infralimbic cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Interaction of stress and alcohol on discriminating fear from safety and reward in male and female rats.Psychopharmacology · 2023Article
- Beyond Fear, Extinction, and Freezing: Strategies for Improving the Translational Value of Animal Conditioning Research.Current topics in behavioral neurosciences · 2023Article
- Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.The American psychologist · 2022Article
- Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure.Neurobiology of stress · 2022Article
- Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence.Nature communications · 2022Article
- Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours.Nature communications · 2022Article
- Stress and sex-dependent effects on conditioned inhibition of fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- On the basis of sex: Differences in safety discrimination vs. conditioned inhibition.Behavioural brain research · 2021Review
- Pre-adolescent stress disrupts adult, but not adolescent, safety learning.Behavioural brain research · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Resistant and generalized fear are hallmark symptoms of Post-Traumatic Stress Disorder (PTSD). Given PTSD is highly comorbid with addiction disorders indicates a maladaptive interaction between fear and reward circuits. To investigate learning processes underlying fear, reward and safety, we trained male rats to discriminate among a fear cue paired with footshock, a reward cue paired with sucrose and an explicit safety cue co-occurring with the fear cue in which no footshocks were delivered. In an attempt to emulate aspects of PTSD, we pre-exposed male rats to a stressor (15 unsignaled footshocks) before training them to fear, reward and safety cues, and subsequent fear and reward extinction. Prior stress did not produce any significant impairments on conditioned inhibition to a safety cue compared to non-stressed controls. However, in subsequent fear extinction, prior stress profoundly impaired fear reduction to an extinguished fear cue. Prior stress also significantly reduced reward seeking to a reward-associated cue throughout training. Together, our data show that prior stress did not affect conditioned inhibition of fear to the same extent as impairing fear extinction. These results have interesting implications on how safety circuits are organized and impacted by stress, leading to possibly new avenues of research on mechanisms of stress disorders, such as PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.