Cerebrospinal fluid MinION sequencing of 16S rRNA gene for rapid and accurate diagnosis of bacterial meningitis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

1. Applying nanopore sequencing in the etiological diagnosis of bloodstream infection.Frontiers in microbiology · 2025
   Review
2. Clinical application and evaluation of metagenomic next-generation sequencing in pathogen detection for suspected central nervous system infections.Scientific reports · 2024
   Article
3. The newest Oxford Nanopore R10.4.1 full-length 16S rRNA sequencing enables the accurate resolution of species-level microbial community profiling.Applied and environmental microbiology · 2023
   Article
4. Predicting β-lactam susceptibility from the genome ofFrontiers in microbiology · 2023
   Article
5. Diagnosis of pathogens causing bacterial meningitis using Nanopore sequencing in a resource-limited setting.Annals of clinical microbiology and antimicrobials · 2022
   Article
6. Nanopore 16S sequencing enhances the detection of bacterial meningitis after neurosurgery.Annals of clinical and translational neurology · 2022
   Article
7. Nanopore sequencing of cerebrospinal fluid of three patients with cryptococcal meningitis.European journal of medical research · 2022
   Article
8. The application of targeted nanopore sequencing for the identification of pathogens and resistance genes in lower respiratory tract infections.Frontiers in microbiology · 2022
   Article
9. Improving the Diagnosis of Bacterial Infections: Evaluation of 16S rRNA Nanopore Metagenomics in Culture-Negative Samples.Frontiers in microbiology · 2022
   Article
10. Toward Establishing Integrated, Comprehensive, and Sustainable Meningitis Surveillance in Africa to Better Inform Vaccination Strategies.The Journal of infectious diseases · 2021
    Article
11. Is Oxford Nanopore sequencing ready for analyzing complex microbiomes?FEMS microbiology ecology · 2021
    Article
12. Evaluating Infectious, Neoplastic, Immunological, and Degenerative Diseases of the Central Nervous System with Cerebrospinal Fluid-Based Next-Generation Sequencing.Molecular diagnosis & therapy · 2021
    Review

Corrections and comments

• Comment on
  Detection of pediatric bacterial meningitis pathogens from cerebrospinal fluid by next-generation sequencing technology.2019
• Comment on
  Next-generation sequencing combined with routine methods to detect the pathogens of encephalitis/meningitis from a Chinese tertiary pediatric neurology center.2019

Authors and funding

21 authors at 6 institutions in 3 countries.

Funding

Abstract

PubMed holds no abstract for this paper.

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