Evidence map›Paper›PMID 31891524›Full record

ArticleJournal of neurophysiology2020

Decreased amplitude and reliability of odor-evoked responses in two mouse models of autism.

Matthew A Geramita, Jing A Wen, Matthew D Rannals, Nathan N Urban

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  4. Article
  5. Hyperexcitability in the Olfactory Bulb and Impaired Fine Odor Discrimination in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  6. Haploinsufficiency ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. Article
  8. Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Review
  10. The Olfactory System as Marker of Neurodegeneration in Aging, Neurological and Neuropsychiatric Disorders.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Matthew A GeramitaDepartment of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jing A WenDepartment of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania.
Matthew D RannalsDepartment of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania.
Nathan N UrbanDepartment of Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Carnegie Mellon University · USCenter for the Neural Basis of Cognition · USUniversity of Pittsburgh · US

Funding

Experience-dependent plasticity of olfactory bulb circuitsR01DC016560 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI URBAN, NATHAN NEAL · 2019 to 2023
$2.1M
Parallel and distinct olfactory bulb output pathways mediated by mitral and tufted cells circuitsR56DC015978 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI URBAN, NATHAN NEAL · 2017 to 2017
$501k
NIDCD NIH HHS R01 DC016560NIDCD NIH HHS R56 DC015978
6 · The paper itself

Abstract

Sensory processing deficits are increasingly recognized as core symptoms of autism spectrum disorders (ASDs). However the molecular and circuit mechanisms that lead to sensory deficits are unknown. We show that two molecularly disparate mouse models of autism display similar deficits in sensory-evoked responses in the mouse olfactory system. We find that both

Indexed as

AnimalsAutism Spectrum DisorderCalciumDisease Models, AnimalFemaleMaleMembrane ProteinsMiceMice, KnockoutMicrofilament ProteinsMicroscopy, Fluorescence, MultiphotonNerve Tissue ProteinsOlfaction DisordersOlfactory BulbOlfactory NerveOlfactory PerceptionCalciumCNTNAP2 protein, mouseMembrane ProteinsMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouseautismcalcium imagingolfactory bulbreliabilitysynaptic deficits

Identifiers

PMID31891524
PMCPMC7191528
OpenAlexW2997646112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.