Evidence map›Paper›PMID 31891519›Full record

ArticleAmerican journal of physiology. Cell physiology2020

Female sex and Western-style diet protect mouse resistance arteries during acute oxidative stress.

Charles E Norton, Nicole L Jacobsen, Shenghua Y Sinkler, Camila Manrique-Acevedo, Steven S Segal

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Reduced cofilin activity as a mechanism contributing to endothelial cell stiffening in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Differential Effects of High Fat Diets on Resilience to HAntioxidants (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Article
  11. Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Nicole L JacobsenDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Shenghua Y SinklerDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Camila Manrique-AcevedoDepartment of Medicine, University of Missouri, Columbia, Missouri.
Steven S SegalDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.ORCID 0000-0001-5667-2154
University of Missouri · USHarry S. Truman Memorial Veterans' Hospital · US

Funding

Intercellular Coordination of Blood Flow ControlR37HL041026 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 2008 to 2018
$3.7M
Estrogen receptor alpha signaling in endothelial cells exacerbates arterial stiffening via upregulation of ENaC in insulin resistant femalesR01HL142770 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MANRIQUE ACEVEDO, CAMILA MARGARITA · 2019 to 2023
$3.7M
Mineralocorticoid and estrogen receptor alpha signaling in the pathogenesis of vascular stiffness in insulin resistant femalesK08HL129074 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MANRIQUE ACEVEDO, CAMILA MARGARITA · 2015 to 2019
$802k
NHLBI NIH HHS K08 HL129074NHLBI NIH HHS R01 HL142770NHLBI NIH HHS R37 HL041026
6 · The paper itself

Abstract

A Western-style diet (WD; high in fat and carbohydrates) increases vascular oxidative stress. We hypothesized that vascular cells adapt to a WD by developing resilience to oxidative stress. Male and female C57BL/6J mice (4 wk of age) were fed a control diet (CD) or a WD for 16-20 wk. Superior epigastric arteries (SEAs; diameter, ~125 µm) were isolated and pressurized for study. Basal reactive oxygen species production was greatest in SEAs from males fed the WD. During exposure to H

Indexed as

Diet, WesternSex CharacteristicsAnimalsEpigastric ArteriesFemaleHydrogen PeroxideMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleOxidative StressVascular ResistanceVasodilationHydrogen Peroxideendothelial cellshydrogen peroxidesmooth muscle cellsTRP channels

Identifiers

PMID31891519
PMCPMC7099517
OpenAlexW2998183464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.