Evidence map›Paper›PMID 31891237›Full record

ArticleStem cells translational medicine2020

Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit

Bingyan J Wang, Roberto Alvarez, Alvin Muliono, Sharon Sengphanith, Megan M Monsanto, Joi Weeks, Roberto Sacripanti, Mark A Sussman

Open access · goldAbstract read
In one paragraph

Article in Stem cells translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bingyan J WangSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.ORCID 0000-0002-3522-2848
Roberto AlvarezSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.
Alvin MulionoSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.
Sharon SengphanithSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.
Megan M MonsantoSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.
Joi WeeksSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.
Roberto SacripantiSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.
Mark A SussmanSDSU Heart Institute and Department of Biology, San Diego State University, San Diego, California.ORCID 0000-0002-0104-4799
San Diego State University · US

Funding

Surgery, Physiology and ImmunohistopathologyP01HL085577 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI BROWN, JOAN HELLER · 2006 to 2017
$18.4M
Regulation of Signal Transduction to Treat Heart FailureR01HL067245 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2001 to 2021
$6.0M
Stem Cell Signaling in the Pathologically Challenged MyocardiumR37HL091102 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2008 to 2017
$3.8M
Beta-adrenergic signaling: double edged sword of myocardial repairR01HL117163 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2013 to 2017
$1.9M
Antagonism of myocardial aging and senescence with Pim-1 kinaseR01HL105759 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2011 to 2015
$1.8M
Resolving myocardial regeneration by tracking commitment of c-Kit+ cellsR01HL135661 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI GUDE, NATALIE ALLEN, SUSSMAN, MARK ALAN · 2017 to 2020
$1.7M
Enhanced Myocardial Repair with CardioClusters and CardioChimerasR01HL122525 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2014 to 2017
$1.5M
Cardioprotection by optimizing mTOR activityR01HL113647 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2013 to 2016
$1.5M
NHLBI NIH HHS P01 HL085577NHLBI NIH HHS R01 HL067245NHLBI NIH HHS R01 HL105759NHLBI NIH HHS R01 HL113647NHLBI NIH HHS R01 HL117163NHLBI NIH HHS R01 HL122525NHLBI NIH HHS R01 HL135661NHLBI NIH HHS R37 HL091102
6 · The paper itself

Abstract

Cardiac interstitial cells (CICs) perform essential roles in myocardial biology through preservation of homeostasis as well as response to injury or stress. Studies of murine CIC biology reveal remarkable plasticity in terms of transcriptional reprogramming and ploidy state with important implications for function. Despite over a decade of characterization and in vivo utilization of adult c-Kit

Indexed as

Cell Culture TechniquesFemaleHumansMaleMyocardiumMyocytes, CardiacStem Cellsadaptationcardiaccell cultureheartinterstitial cell

Identifiers

PMID31891237
PMCPMC7180292
OpenAlexW2997790816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.