Evidence map›Paper›PMID 31891220›Full record

ArticleCellular microbiology2020

Bacterial injection machines: Evolutionary diverse but functionally convergent.

Sophie Bleves, Jorge E Galán, Matxalen Llosa

Open access · greenAbstract read
In one paragraph

Article in Cellular microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Illuminating type IV secretion-mediated DNA trafficking through long filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Sophie BlevesLISM (Laboratoire d'Ingénierie des Systèmes Macromoléculaires-UMR7255), IMM (Institut de Microbiologie de la Méditerranée), Aix-Marseille Univ and CNRS, Marseille, France.ORCID 0000-0002-9406-3437
Jorge E GalánDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut.
Matxalen LlosaInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-SODERCAN, Santander, Spain.ORCID 0000-0002-4826-2240
Centre National de la Recherche Scientifique · FRUniversidad de Cantabria · ESYale University · US

Funding

MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR37AI030492 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2000 to 2024
$10.1M
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR01AI030492 · NIAID · YALE UNIVERSITY · PI Jorge E Galan · 1995 to 2026
$3.1M
NIAID NIH HHS R01 AI030492NIAID NIH HHS R37 AI030492
6 · The paper itself

Abstract

Many human pathogens use Type III, Type IV, and Type VI secretion systems to deliver effectors into their target cells. The contribution of these secretion systems to microbial virulence was the main focus of a workshop organised by the International University of Andalusia in Spain. The meeting addressed structure-function, substrate recruitment, and translocation processes, which differ widely on the different secretion machineries, as well as the nature of the translocated effectors and their roles in subverting the host cell. An excellent panel of worldwide speakers presented the state of the art of the field, highlighting the involvement of bacterial secretion in human disease and discussing mechanistic aspects of bacterial pathogenicity, which can provide the bases for the development of novel antivirulence strategies.

Indexed as

BacteriaBacterial ProteinsBacterial Secretion SystemsHumansProtein TransportSpainType III Secretion SystemsType IV Secretion SystemsType VI Secretion SystemsVirulenceBacterial ProteinsBacterial Secretion SystemsType III Secretion SystemsType IV Secretion SystemsType VI Secretion Systemsantibacterialbacterial secretioneffector proteinhost subversionmachinery assemblymicrobial virulencepathogenicityprotein translocationtoxinType III secretion systemType IV secretion systemType VI secretion system

Identifiers

PMID31891220
PMCPMC7138736
OpenAlexW2998583759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.