Evidence map›Paper›PMID 31891152›Full record

ArticleVaccine: X2020

Allopurinol therapy provides long term clinical improvement, but additional immunotherapy is required for sustained parasite clearance, in

Leopoldo F M Nascimento, Dayane Francisca Higino Miranda, Luana D Moura, Flaviane A Pinho, Guilherme Loureiro Werneck, Ricardo Khouri, Steven G Reed, Malcolm S Duthie, Aldina Barral, Manoel Barral-Netto and 1 more

Open access · goldAbstract read
In one paragraph

Article in Vaccine: X, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Knowledge mapping of risk mitigation measures against vector-borne diseases.EFSA journal. European Food Safety Authority · 2026
    Article
  5. Article
  6. Treatment ofMicroorganisms · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Clinical and parasitological impact of short-term treatment using miltefosine and allopurinol monotherapy or combination therapy in canine visceral leishmaniasis.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2022
    Article
  15. Article
  16. Microorganisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Leopoldo F M NascimentoUniversidade Federal do Piauí, Departamento de Morfofisiologia Veterinária, Teresina, PI, Brazil.
Dayane Francisca Higino MirandaUniversidade Federal do Piauí, Departamento de Morfofisiologia Veterinária, Teresina, PI, Brazil.
Luana D MouraUniversidade Federal do Piauí, Departamento de Morfofisiologia Veterinária, Teresina, PI, Brazil.
Flaviane A PinhoUniversidade Federal da Bahia, Faculdade de Medicina, Salvador, BA, Brazil.
Guilherme Loureiro WerneckUniversidade Federal do Rio de Janeiro, Instituto de Estudos em Saúde Coletiva, Rio de Janeiro, RJ, Brazil.
Ricardo KhouriFundação Oswaldo Cruz- Fiocruz, Instituto Gonçalo Moniz, Salvador, BA, Brazil.
Steven G ReedInfectious Diseases Research Institute, Seattle, WA 98102, USA.
Malcolm S DuthieInfectious Diseases Research Institute, Seattle, WA 98102, USA.
Aldina BarralFundação Oswaldo Cruz- Fiocruz, Instituto Gonçalo Moniz, Salvador, BA, Brazil.
Manoel Barral-NettoFundação Oswaldo Cruz- Fiocruz, Instituto Gonçalo Moniz, Salvador, BA, Brazil.
Maria S P CruzUniversidade Federal do Piauí, Departamento de Morfofisiologia Veterinária, Teresina, PI, Brazil.
Universidade Federal da Bahia · BRUniversidade Federal do Piauí · BRInfectious Disease Research Institute · USUniversidade Federal do Rio de Janeiro · BR

Funding

LEISHMANIA ANTIGENS DEFINES BY IMMUNE RESPONSESR01AI025038 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI REED, STEVEN GREGORY · 1987 to 2016
$5.6M
NIAID NIH HHS R01 AI025038
6 · The paper itself

Abstract

There is little evidence that current control strategies for canine leishmaniosis (CanL), the veterinary disease caused by

Indexed as

Canine visceral leishmaniasisCanL, canine leishmaniosisClinical signsDrugGLA, glycopyranosyl lipidIFN, interferonIL, interleukinMPL, monophosphoryl lipid AParasiteSE, stable emulsionSLA, Second generation Lipid AdjuvantTh1, T helper 1-like cellsTLR, Toll-like receptorVaccineVL, visceral leishmaniasis

Identifiers

PMID31891152
PMCPMC6928333
OpenAlexW2991368228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.