ArticleKidney international reports2019
Vitamin D Metabolic Ratio and Risks of Death and CKD Progression.
Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis.The American journal of clinical nutrition · 2022Trial
- Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism.The Journal of clinical endocrinology and metabolism · 2025 · on this mapArticle
- Investigation of the Vitamin D Metabolite Ratio (VMR) as a Marker of Functional Vitamin D Deficiency: Findings from the SarcoPhAge Cohort.Nutrients · 2024Article
- Value of Vitamin D Metabolite Ratios in 3 Patients as Diagnostic Criteria to Assess Vitamin D Status.JCEM case reports · 2024 · on this mapArticle
- Risk factors for hip and vertebral fractures in chronic kidney disease: the CRIC study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism.medRxiv : the preprint server for health sciences · 2024Article
- The Vitamin D Metabolite Ratio Is Associated With Volumetric Bone Density in Older Men.The Journal of clinical endocrinology and metabolism · 2024Article
- Association of serum 25-hydroxyvitamin D with cardiovascular and all-cause mortality in patients with chronic kidney disease: NHANES 2007‒2018 results.Clinics (Sao Paulo, Brazil) · 2024Article
- Review
- Vitamin D Metabolites and Risk of Cardiovascular Disease in Chronic Kidney Disease: The CRIC Study.Journal of the American Heart Association · 2023Article
- The Vitamin D Metabolite Ratio (VMR) is a Biomarker of Vitamin D Status That is Not Affected by Acute Changes in Vitamin D Binding Protein.Clinical chemistry · 2023Article
- Vitamin D supplementation in children and young adults with persistent proteinuria secondary to glomerular disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Biomarkers of Vitamin D Metabolism and Hip and Vertebral Fracture Risk: The Multi-Ethnic Study of Atherosclerosis.JBMR plus · 2022Article
- Validation of the 24,25-dihydroxyvitamin DThe Journal of steroid biochemistry and molecular biology · 2022Article
- Total and free vitamin D metabolites in patients with primary hyperparathyroidism.Journal of endocrinological investigation · 2022Article
- Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women.Nutrients · 2021Article
- The Vitamin D Metabolite Ratio Is Independent of Vitamin D Binding Protein Concentration.Clinical chemistry · 2021Article
- Vitamin D metabolites and the gut microbiome in older men.Nature communications · 2020Article
Corrections and comments
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Authors and funding
20 authors at 13 institutions in 1 country.
Funding
Abstract
introductionAssessment of impaired vitamin D metabolism is limited by lack of functional measures. CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic ratio, VDMR), is induced by 1,25-dihydroxyvitamin D and may assess tissue-level activity. We tested associations of the VDMR with risks of death and progression to end-stage renal disease (ESRD) in patients with chronic kidney disease (CKD).
methodsWe studied participants from the Chronic Renal Insufficiency Cohort (CRIC), which included a random subset of 1080 CRIC participants plus additional participants who experienced ESRD or died (case cohort study design). Serum 24,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 was measured 1 year after enrollment. The primary outcomes included death and progression to ESRD. Using inverse probability weighting, we tested associations of VDMR (24,25[OH]
resultsThere were a total of 708 ESRD events and 650 deaths events over mean (SD) follow-up periods of 4.9 (2.9) years and 6.5 (2.5) years, respectively. Lower VDMR was associated with increased risk of ESRD prior to adjusting for kidney function (hazard ratio [HR], 1.80 per 20 pg/ng lower VDMR; 95% confidence interval [CI], 1.56-2.08), but not with adjustment for kidney function (HR, 0.94 per 20 pg/ng; 95% CI, 0.81-1.10). Lower VDMR was associated with modestly increased mortality risk, including adjustment for kidney function (HR, 1.18 per 20 pg/ng; 95% CI, 1.02-1.36).
conclusionLower VDMR, a measure of CYP24A1-mediated vitamin D clearance, was significantly associated with all-cause mortality but not with progression to ESRD in patients with CKD.
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