ArticleDiagnostic and prognostic research2019
Targeted test evaluation: a framework for designing diagnostic accuracy studies with clear study hypotheses.
Article in Diagnostic and prognostic research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of active pulmonary tuberculosis screening during detention admission: a systematic review.Journal of medicine and life · 2024Pooled it
- Small Study Effects in Diagnostic Imaging Accuracy: A Meta-Analysis.JAMA network open · 2022Pooled it
- Implementation of digital remote postoperative monitoring in routine practice: a qualitative study of barriers and facilitators.BMC medical informatics and decision making · 2024Trial
- Diagnostic accuracy of magnetically guided capsule endoscopy with a detachable string for detecting oesophagogastric varices in adults with cirrhosis: prospective multicentre study.BMJ (Clinical research ed.) · 2024Trial
- A diagnostic phase III/IV seamless design to investigate the diagnostic accuracy and clinical effectiveness using the example of HEDOS and HEDOS II.Statistical methods in medical research · 2024Trial
- Article
- Diagnostic Yield of Comprehensive Etiologic Evaluation in Young Adults with Ischemic Stroke: Toward a Phenotype-Driven Approach.Journal of clinical medicine · 2026Article
- Minimally acceptable criteria and required sample size for an accuracy study of non-invasive prenatal testing of sickle cell disease in screen positive women in England: results of a decision tree model.Diagnostic and prognostic research · 2026Article
- Modelling the cost-effectiveness of non-invasive prenatal testing in the English sickle cell and thalassaemia screening pathway.Diagnostic and prognostic research · 2026Article
- An exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons.Aging clinical and experimental research · 2026Article
- Targeted test evaluation: five suggestions for refining the framework for designing diagnostic accuracy studies with clear study hypotheses.Diagnostic and prognostic research · 2025Article
- Evaluating the Performance of Non-invasive Tests for Colorectal Cancer: Statistical Considerations.Digestive diseases and sciences · 2025Article
- A Seamless Design for the Combination of a Case-Control and a Cohort Diagnostic Accuracy Study.Statistics in medicine · 2025Article
- Snake Fungal Disease (Ophidiomycosis) in Northern Pine Snakes (Journal of fungi (Basel, Switzerland) · 2025Article
- Community Health Workers Equipped with an mHealth Application Can Accurately Diagnose Hypertension in Rural Guatemala.Global heart · 2025Article
- Statistical inference for diagnostic test accuracy studies with multiple comparisons.Statistical methods in medical research · 2024Article
- Snake Fungal Disease in Free-Ranging Northern Pine Snakes (Journal of fungi (Basel, Switzerland) · 2024Article
- Sample size determination for point-of-care COVID-19 diagnostic tests: a Bayesian approach.Diagnostic and prognostic research · 2023Article
- Diagnostic accuracy of a rapid nucleic acid test for group A streptococcal pharyngitis using saliva samples: protocol for a prospective multicenter study in primary care.Diagnostic and prognostic research · 2023Article
- Assessment of clinical utility and predictive potential of pre-chemotherapy soluble urokinase plasminogen activator receptor: Observational single center study.Biomolecules & biomedicine · 2023Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most randomized controlled trials evaluating medical interventions have a pre-specified hypothesis, which is statistically tested against the null hypothesis of no effect. In diagnostic accuracy studies, study hypotheses are rarely pre-defined and sample size calculations are usually not performed, which may jeopardize scientific rigor and can lead to over-interpretation or "spin" of study findings. In this paper, we propose a strategy for defining meaningful hypotheses in diagnostic accuracy studies. Based on the role of the index test in the clinical pathway and the downstream consequences of test results, the consequences of test misclassifications can be weighed, to arrive at minimally acceptable criteria for pre-defined test performance: levels of sensitivity and specificity that would justify the test's intended use. Minimally acceptable criteria for test performance should form the basis for hypothesis formulation and sample size calculations in diagnostic accuracy studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.