ReviewLaryngoscope investigative otolaryngology2019
Squamous cell carcinoma of the temporal bone: A current review.
Review in Laryngoscope investigative otolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Temporal Bone Squamous Cell Carcinoma: Molecular Markers Involved in Carcinogenesis, Behavior, and Prognosis: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Single-Cell RNA Sequencing Reveals the Heterogeneity and Microenvironment of Temporal Bone Squamous Cell Carcinoma.Clinical and experimental otorhinolaryngology · 2026Article
- Tumor stage and treatment outcomes in external auditory canal SCC: a multicenter cohort study.International journal of surgery (London, England) · 2026Article
- Malignant external auditory canal and temporal bone tumours: Clinical outcomes in Cape Town, South Africa.Journal of the colleges of medicine of South Africa · 2026Article
- Survival outcomes and prognostic factors in temporal bone malignancies: A retrospective cohort of 20 patients.Oncology letters · 2026Article
- [Skull base surgery-where do we stand?]HNO · 2025Review
- Rare Clinical Presentation of Diffuse Large B-Cell Lymphoma as Otitis Media and Mastoiditis.Journal of audiology & otology · 2025Article
- Temporal Bone Carcinoma Masquerading as Complicated Chronic Otitis Media.Clinical case reports · 2025Article
- Analysis of L1 Cell Adhesion Molecule and Fucosyltransferase 8 Expression in Cells After Stretch and Human EACSCC Tissue.The journal of international advanced otology · 2025Article
- Treatment outcomes and prognostic factors in external auditory canal squamous cell carcinoma.PloS one · 2025Article
- Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal.Cancers · 2024Article
- Possible thoracic metastasis from squamous cell carcinoma of the external auditory canal: A case report.Clinical case reports · 2024Article
- A case of otoliquorrhoea secondary to immunotherapy response in head and neck cutaneous squamous cell carcinoma. When abrupt response may worry the physician.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Article
- Fat-augmented Temporal Fascia Flap for Defect Coverage following External Auditory Canal Cancer Resection.Plastic and reconstructive surgery. Global open · 2024Article
- Article
- Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center.Laryngoscope investigative otolaryngology · 2024Article
- Temporal bone squamous cell carcinoma: Aggressive behavior coursing with cerebellar invasion and hydrocephalus.Surgical neurology international · 2024Article
- Role of the otologist/neurotologist in managing auricular and periauricular cutaneous malignancies: A 10-year otologic oncology experience.Laryngoscope investigative otolaryngology · 2023Article
- Preoperative simulation using three-dimensional printer in four temporal bone surgeries.Clinical case reports · 2023Article
- Survival Outcomes in Squamous Cell Carcinoma of the External Auditory Canal: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe rarity of temporal bone squamous cell carcinoma (TBSCC) precludes a clear understanding of the disease and approach to its management. This review provides general background on the disease and discusses the current and emerging oncologic and rehabilitative management options. DATA SOURCES: PubMed literature review.
methodsA review of the current literature was conducted to assess and collate up-to-date information regarding TBSCC management.
resultsTBSCC is a rare and aggressive disease arising in the ear canal, temporal bone, or extratemporal sites. Prior radiation, chronic ear disease, or habitual ear picking may contribute to primary disease development. Because the symptoms of TBSCC and benign otologic disease are similar, TBSCC diagnosis may be delayed, allowing the tumor time to spread throughout the anatomically intricate temporal bone. The extent of the disease is determined based on imaging and is usually staged with the Pittsburgh Staging System. Temporal bone resection with parotidectomy and neck dissection is the current standard of care. Survival is generally good for early disease and poor for advanced disease, but chemotherapy is emerging as a promising treatment option. Auditory rehabilitation with osseointegrated hearing aids is recommended at initial oncologic resection.
conclusionsThe knowledge of and outcomes for TBSCC have improved with time, but because of the aggressive nature of the disease and the anatomic intricacy of the temporal bone, TBSCC treatment is complex and should be delivered by a multidisciplinary team. Inter-institutional collaboration may accelerate research for this rare disease. LEVEL OF EVIDENCE: 5.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.