ReviewLaryngoscope investigative otolaryngology2019
Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials.
Review in Laryngoscope investigative otolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Scalar position characteristics and translocation rates of different lateral wall electrodes within the cochlear basal turn: a cone beam computed tomography study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Comparative spatiotemporal dynamics of access resistance, polarization impedance, and nested bipolar impedance in standard and dexamethasone-eluting electrode arrays.Hearing research · 2026Article
- Electrode impedance in cochlear implantation: determinants, dynamics, and clinical implications.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Manual Insertion of Cochlear Implant Electrodes Versus Robot-Assisted Insertion and Analysis by Micro-CT: A Temporal Bone Study.Audiology research · 2026Article
- Effect of early activation and perimodiolar electrodes on cochlear implant impedance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Factors Affecting Audiometric and Speech Perception Outcomes in Hybrid Cochlear Implant Recipients.The Laryngoscope · 2026Article
- Dynamic and living devices for overcoming fibrosis of implanted biomaterials.Bioengineering & translational medicine · 2026Review
- Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation.Frontiers in toxicology · 2026Article
- Diminished fibrotic encapsulation and comparable physicochemical properties of poly (styrene-Frontiers in bioengineering and biotechnology · 2026Article
- Understanding the Mechanisms Driving Fibrosis Following Cochlear Implantation-Lessons from Other Tissues.Cells · 2025Review
- Radiation-free cochlear implant position estimation in pediatric patients using impedance telemetry.BMC pediatrics · 2025Article
- Exploring AAV-Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Clinical and Instrumental Evaluation of Vestibular Function Before and After Cochlear Implantation in Adults.Audiology research · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- PET imaging of tissue reactions in the implanted cochlea: results of a pilot study.Frontiers in immunology · 2025Article
- Electrode impedance dynamics in sequential cochlear implant users: insights into cochlear immunity.Frontiers in immunology · 2025Article
- The influence of CI electrode array design on the preservation of residual hearing.Frontiers in neurology · 2025Article
- App-based daily self-measurement of impedance in cochlear implant users.Frontiers in neurology · 2025Article
- Electrical Bioimpedance-Based Monitoring of Intracochlear Tissue Changes After Cochlear Implantation.Sensors (Basel, Switzerland) · 2024Article
- Molded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model.Pharmaceutics · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveTo report current knowledge on the topic of intracochlear fibrosis and the foreign body response following cochlear implantation (CI).
methodsA literature search was performed in PubMed to identify peer-reviewed articles. Search components included "cochlear implant," "Foreign body response (FBR)," and "fibrosis." Original studies and review articles relevant to the topic were included.
resultsNinety peer-reviewed articles describing the foreign body response or intracochlear fibrosis following CI were included.
conclusionsIntracochlear fibrosis following CI represents a significant limiting factor for the success of CI users. Several strategies have been employed to mitigate the foreign body response within the cochlea including drug delivery systems and modifications in surgical technique and electrode design. A better understanding of the FBR has the potential to improve CI outcomes and the next generation of cochlear prostheses.
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Registered trials
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