Evidence map›Paper›PMID 31890867›Full record

ArticleMolecular therapy oncolytics2019

Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection.

Lianwen Zhang, Lukkana Suksanpaisan, Huailei Jiang, Timothy R DeGrado, Stephen J Russell, Ming Zhao, Kah-Whye Peng

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Multiplexed imaging of radionuclides.Nature biomedical engineering · 2025
    Review
  3. Recent developments in translational imaging of in vivo gene therapy outcomes.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Radionuclide imaging of apoptosis for clinical application.European journal of nuclear medicine and molecular imaging · 2022
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lianwen ZhangDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Lukkana SuksanpaisanImanis Life Sciences, Rochester, MN, USA.
Huailei JiangDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Timothy R DeGradoDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Stephen J RussellDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Ming ZhaoNorthwestern University, Chicago, IL, USA.
Kah-Whye PengDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USNorthwestern University · US

Funding

(PQD5) imaging systemic tissue injuries induced by anticancer drugsR01CA185214 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI O'HALLORAN, THOMAS V, ZHAO, MING · 2014 to 2017
$2.0M
Intravenous Administration of Vesicular Stomatitis VectorsR01CA175795 · NCI · MAYO CLINIC ROCHESTER · PI PENG, KAH-WHYE · 2014 to 2017
$1.5M
A SPECT_CT Scanner for Preclinical Imaging StudiesS10OD016398 · OD · NORTHWESTERN UNIVERSITY · PI ZHAO, MING · 2014 to 2014
$600k
NCI NIH HHS R01 CA175795NCI NIH HHS R01 CA185214NIH HHS S10 OD016398
6 · The paper itself

Abstract

Noninvasive dual-imaging methods that provide an early readout on tumor permissiveness to virus infection and tumor cell death could be valuable in optimizing development of oncolytic virotherapies. Here, we have used the sodium iodide symporter (NIS) and

Identifiers

PMID31890867
PMCPMC6931109
OpenAlexW2980042023

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.