Evidence map›Paper›PMID 31890856›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2019

Associations of hemoglobin A1c with cognition reduced for long diabetes duration.

Jeremy M Silverman, James Schmeidler, Pearl G Lee, Neil B Alexander, Michal Schnaider Beeri, Elizabeth Guerrero-Berroa, Rebecca K West, Mary Sano, Martina Nabozny, Carolina Rodriguez Alvarez

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01736124 (Computerized Cognitive Training to Improve Cognition in Diabetic Elderly Veterans), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01736124 phase4completednot on this map

Computerized Cognitive Training to Improve Cognition in Diabetic Elderly Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2015 to 2018Enrolled199ConditionsDiabetes Mellitus, Type 2Armscomputerized cognitive training, control games
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeremy M SilvermanResearch & Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
James SchmeidlerDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pearl G LeeDepartment of Internal Medicine and Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
Neil B AlexanderDepartment of Internal Medicine and Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
Michal Schnaider BeeriDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Elizabeth Guerrero-BerroaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rebecca K WestDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mary SanoResearch & Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
Martina NaboznyDepartment of Internal Medicine and Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
Carolina Rodriguez AlvarezDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular diseaseR01AG061093 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SCHNAIDER BEERI, MICHAL · 2019 to 2024
$4.3M
Cardiovascular RF and Successful Cognitive Aging in Very Old Male VeteransI01CX000900 · VA · JAMES J PETERS VA MEDICAL CENTER · PI SILVERMAN, JEREMY M. · 2014 to 2019
–
Computerized Cognitive Training to Improve Cognition in Diabetic Elderly VeteransI01HX000828 · VA · JAMES J PETERS VA MEDICAL CENTER · PI SILVERMAN, JEREMY M. · 2014 to 2021
–
CSRD VA I01 CX000900HSRD VA I01 HX000828NIA NIH HHS P30 AG024824NIA NIH HHS R01 AG061093NIDDK NIH HHS P30 DK020572RRD VA IK2 RX001190
6 · The paper itself

Abstract

introductionAssociations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration.

methodsThe interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 "young-old" veterans (mean age = 70) with type 2 diabetes.

resultsThe predicted interactions were significant for overall cognition and attention, but not executive functions/language and memory. DISCUSSION: Findings extend the Protected Survivor Model to a "young-old" sample, from the very old. This model suggests focusing on individuals with good cognition despite prolonged high risk when seeking protective factors.

Indexed as

Cognitive functionDiabetes durationHemoglobin A1cProtected survivorProtective factorsRisk factorsType 2 diabetes

Identifiers

PMID31890856
PMCPMC6926347

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.