ArticleInternational journal of pediatrics & adolescent medicine2019
Clinical significance of IgM deposition in pediatric minimal change disease.
Article in International journal of pediatrics & adolescent medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
- Comparison between characteristics of immunoglobulin M nephropathy and other glomerular diseases.Kidney research and clinical practice · 2025Article
- Article
- IgM deposition is a risk factor for delayed remission and early relapse of the pediatric minimal change disease.Frontiers in pediatrics · 2023Article
- Clinical characteristics and outcomes of idiopathic membranous nephropathy with glomerular IgM deposits.Clinical and experimental medicine · 2022Article
- Clinical relevance of glomerular IgM deposition in patients with lupus nephritis.BMC immunology · 2021Article
- IgM mesangial deposition as a risk factor for relapses of adult-onset minimal change disease.BMC nephrology · 2021Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundIdiopathic nephrotic syndrome (INS) is a common pediatric disease. Minimal change disease (MCD) is the most common histopathological subtype and usually has good prognosis. However, in less common presentations, INS may have an unusual course that makes renal biopsy a necessity to identify its etiology. Immunoglobulin M (IgM) occasionally deposits in the mesangium and can be seen under immunofluorescence (IF). The role of IgM is controversial in MCD. It is likely associated with less favorable outcomes for MCD. This study aims to investigate the clinical significance of mesangial IgM deposits on the outcome of MCD in a pediatric population.
methodsIn this retrospective cohort study, we obtained native kidney biopsy samples from 192 children who were diagnosed with MCD from 2003 to 2014. The samples were divided into groups according to the histopathological deposition of IgM in biopsies under IF. The group for which biopsies showed IgM was labeled as IgM + IF (n = 77), and the group for which biopsies were without IgM was labeled as IgM-IF (n = 115). We reviewed hypertension, hematuria, and estimated glomerular filtration rate (eGFR) at the time of presentation to our institute; response to steroid therapy (remission, dependence, frequent relapses, and resistance) and response after adjuvant immunosuppressive therapy (complete remission, partial remission, frequent relapses, and no response) when indicated; development of chronic kidney disease (CKD) and end-stage renal disease during the course of the disease (ESRD).
resultsOur results showed that mesangial IgM deposition in MCD showed significant statistical association with hypertension at the time of presentation (
conclusionsOur study showed that IgM deposition in MCD showed statistical association with hypertension by the time the patient presented to our institute, development of steroid dependence, and CKD. IgM may play a role in MCD. However, we recommend a prospective study to verify the role of IgM in MCD outcomes.
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