Evidence map›Paper›PMID 31890716›Full record

ArticleBurns & trauma2019

Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model.

Yajun Song, Yang Li, Ya Xiao, Wengang Hu, Xu Wang, Pei Wang, Xiaorong Zhang, Jiacai Yang, Yong Huang, Weifeng He and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  15. The Anti-Inflammatory Effect and Mucosal Barrier Protection ofFrontiers in cellular and infection microbiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yajun Song *1Department of Urology, Xinqiao Hospital, the Third Military Medical University, No.83 Xinqiao Street, Shapingba District, Chongqing, 400038 China.
Yang Li *1Department of Urology, Xinqiao Hospital, the Third Military Medical University, No.83 Xinqiao Street, Shapingba District, Chongqing, 400038 China.
Ya Xiao1Department of Urology, Xinqiao Hospital, the Third Military Medical University, No.83 Xinqiao Street, Shapingba District, Chongqing, 400038 China.
Wengang Hu1Department of Urology, Xinqiao Hospital, the Third Military Medical University, No.83 Xinqiao Street, Shapingba District, Chongqing, 400038 China.
Xu Wang1Department of Urology, Xinqiao Hospital, the Third Military Medical University, No.83 Xinqiao Street, Shapingba District, Chongqing, 400038 China.
Pei Wang2Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038 China.
Xiaorong Zhang2Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038 China.
Jiacai Yang2Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038 China.
Yong Huang2Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038 China.
Weifeng He2Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038 China.
Chibing Huang1Department of Urology, Xinqiao Hospital, the Third Military Medical University, No.83 Xinqiao Street, Shapingba District, Chongqing, 400038 China.
Army Medical University · CNXinqiao Hospital · CNSouthwest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe intestinal barrier integrity can be disrupted due to burn injury, which is responsible for local and systemic inflammatory responses. Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage. Interleukin-17A (IL-17A) plays a critical role in inflammatory diseases. However, the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood. In this study, we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury, and furthermore, we sought to determine the early source of IL-17A in the intestine.

methodsMouse burn model was successfully established with infliction of 30% total body surface area scald burn. The histopathological manifestation, intestinal permeability, zonula occludens-1 expression, pro-inflammatory cytokines were determined with or without IL-17A-neutralization. Flow cytometry was used to detect the major source of IL-17A

resultsBurn caused intestinal barrier damage, increase of intestinal permeability, alteration of zonula occludens-1 expressions, elevation of IL-17A, IL-6, IL-1β and tumor necrosis factor-α (TNF-α), whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption, maintained zonula occludens-1 expression, and noticeably, inhibited pro-inflammatory cytokines elevation. In addition, we observed that the proportion of intestinal IL-17A

conclusionsThe main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines, and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined. Furthermore, Vγ4

Indexed as

BurnIL-17AInterleukin-17AIntestinal mucosa barrierPro-inflammatory cytokinesVγ4+ T cells

Identifiers

PMID31890716
PMCPMC6933641
OpenAlexW2996893983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.