Evidence map›Paper›PMID 31890685›Full record

ArticleJournal of diabetes and metabolic disorders2019

The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials.

Reza Tabrizi, Afshin Borhani-Haghighi, Naghmeh Mirhosseini, Kamran B Lankarani, Ahmad Naghibzadeh-Tahami, Maryam Akbari, Seyed Taghi Heydari, Mojgan Sangari, Fariba Kolahdooz, Fariba Raygan and 1 more

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Article in Journal of diabetes and metabolic disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reza Tabrizi1Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Afshin Borhani-Haghighi2Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Naghmeh Mirhosseini3School of Public Health, University of Saskatchewan, Saskatoon, SK Canada.
Kamran B Lankarani4Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Ahmad Naghibzadeh-Tahami5Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Maryam Akbari1Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Taghi Heydari4Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Mojgan Sangari6Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Fariba Kolahdooz7Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada.
Fariba Raygan8Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Zatollah Asemi9Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.ORCID 0000-0001-5265-4792

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveStroke is a devastating condition with long-term comorbidities including metabolic abnormalities. Alpha lipoic acid (ALA), with its antioxidant properties, might improve metabolic status of patients, though current evidence is still inclusive. This systematic review of randomized controlled trials (RCTs) was conducted to summarize the existing evidence regarding the effects of ALA supplementation on fasting glucose and lipid profiles among patients with stroke.

methodsWe searched Cochrane Library, EMBASE, MEDLINE, and Web of Science from 1990 until April 5th, 2018. The relevant randomized-controlled articles, based on defined key words, were included in the analyses. Two independent researchers investigated study eligibility, extracted data, and assessed the risk of bias for included studies. Heterogeneity among included studies was tested using Q-test and I

resultsA total of five studies (140 patients in each intervention group) were included in our meta-analysis. The findings showed that ALA supplementation significantly decreased fasting glucose levels (WMD -36.93 mg/dL; 95% CI, -65.58, -8.28;

conclusionsThis meta-analysis suggested the beneficial impacts of ALA supplementation in improving fasting glucose of patients diagnosed with stroke.

Indexed as

Alpha-lipoic acidLipid profilesMeta-analysisStroke

Identifiers

PMID31890685
PMCPMC6915248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.