ArticleJournal of diabetes and metabolic disorders2019
Lean body mass and risk of type 2 diabetes - a Danish cohort study.
Article in Journal of diabetes and metabolic disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review.Acta diabetologica · 2025Pooled it
- The Influence of Body Fat Percentage on Physiological Responses and Performance in Professional Soccer Players During a Soccer Game Simulation Protocol on a Treadmill.Sports (Basel, Switzerland) · 2026Article
- Prediabetes Phenotypes and Adiposity Patterns: Findings From a Population-Based Study.Journal of diabetes research · 2026Article
- Data-driven abdominal phenotypes of type 2 diabetes in lean, overweight, and obese cohorts from computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Lean body mass index and the risk of diabetes onset: A nationwide epidemiological cohort study.Journal of diabetes investigation · 2025Article
- Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women.Metabolism open · 2024Article
- More appendicular lean mass relative to body mass index is associated with lower incident diabetes in middle-aged adults in the CARDIA study.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Article
- Association of predicted fat mass and lean body mass with diabetes: a longitudinal cohort study in an Asian population.Frontiers in nutrition · 2023Article
- Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes.International journal of molecular sciences · 2022Review
- Testing the Utility of Polygenic Risk Scores for Type 2 Diabetes and Obesity in Predicting Metabolic Changes in a Prediabetic Population: An Observational Study.International journal of molecular sciences · 2022Observational
- Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.Journal of diabetes investigation · 2022Article
- Commentary on whole-grain intake and pancreatic cancer risk-the danish, diet, cancer and health cohort by SchachtHepatobiliary surgery and nutrition · 2021Article
- Sarcopenia and Appendicular Muscle Mass as Predictors of Impaired Fasting Glucose/Type 2 Diabetes in Elderly Women.Nutrients · 2021Article
- Hostile personality as a risk factor for hyperglycemia and obesity in adult populations: a systematic review.Journal of diabetes and metabolic disorders · 2020Review
- The Pathophysiology of Type 2 Diabetes Mellitus in Non-obese Individuals: An Overview of the Current Understanding.Cureus · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExcess body fat is a commonly known risk factor for type 2 diabetes. However, whether lean body mass, or fat free mass, could have a protective effect against type 2 diabetes, remains unclear. The aim of this study was to explore the association between lean body mass, fat mass and type 2 diabetes.
methodsThis study used data from the Danish Diet, Cancer and Health cohort of 37,053 men and women, aged 50-64 years at baseline (1993-1997). The exposure was measurements of body composition using bioelectrical impedance analysis. Incident diabetes during follow-up was determined through linkage to the Danish National Diabetes Register. Cox proportional hazards regression analysis was used to estimate HR and 95%CI for the association between lean body mass and incident type 2 diabetes, with and without adjustment for fat mass. A sensitivity analysis was performed, excluding cases of incident type 2 diabetes within the first 2 years of follow-up.
resultsWhen adjusted for fat mass, the main analysis showed non-linear inverse association between lean body mass and risk of diabetes for men, but not for women. However, the sensitivity analysis found no association for either men or women.
conclusionsLean body mass was not associated with incident type 2 diabetes when excluding cases that may have been subclinical at baseline. The results imply that public health should focus on reduction of fat mass for diabetes prevention.
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