ArticleJournal of diabetes and metabolic disorders2019
Investigating the effects of endurance, resistance and combined training on reproductive hormones and sperm parameters of streptozotocin-nicotinamide diabetic male rats.
Article in Journal of diabetes and metabolic disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04732611 (Effects of Pilates Exercises Versus Walking on Mechanical and Vascular Variables of Individuals With Type 2 Diabetes Mellitus), which is not on this map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Pilates Exercises Versus Walking on Mechanical and Vascular Variables of Individuals With Type 2 Diabetes Mellitus: Randomized Clinical Trial
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Effectiveness of exercise interventions on sperm quality: a systematic review and network meta-analysis.Frontiers in endocrinology · 2025Pooled it
- The Role of Exercise to Reduce the Impact of Diabetes in the Seminal Quality: A Systematic Review.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Endogenous transient doping: physical exercise acutely increases testosterone levels-results from a meta-analysis.Journal of endocrinological investigation · 2020Pooled it
- Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats.Iranian journal of medical sciences · 2026Article
- Understanding the impact of streptozotocin on diabetic male infertility: perspectives from rodent models and pharmacological networking.BMC pharmacology & toxicology · 2025Review
- Optimal Exercise Intensity for Enhancing Sperm Parameters: A Network Meta-Analysis of Rodent Studies.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Diabetes-induced male infertility: potential mechanisms and treatment options.Molecular medicine (Cambridge, Mass.) · 2024Review
- Dose-response association between 24-hour total movement activity and testosterone deficiency in adult males.Frontiers in endocrinology · 2023Article
- Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target.Metabolites · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDiabetes mellitus type 2 with damaging effects on reproductive hormones and sperm quality parameters can often cause infertility in men. The aim of this study was to evaluate the effects of endurance, resistance and concurrent training on reproductive hormones, sperm parameter in the diabetic type 2 male rats.
methodsIn this experimental study 60 Wistar rats (200 ± 50 g) were randomly assigned into 5 groups: control; diabetic; diabetic endurance training; diabetic resistance training and diabetic concurrent training. For inducing diabetes, after 12 hours of food starvation nicotinamide (120 mg/kg) and STZ (65 mg/kg) were intraperitoneally injected. Twenty-four hours after the last training session, left epididymis of the rats was examined for studying sperm parameters and blood serum samples were examined for evaluating reproductive hormones. Data were analyzed using one-way ANOVA and Turkey's Post Hoc test.
resultsTen weeks of endurance and concurrent training induced significant decrease in the blood glucose in comparison to the diabetic group (
conclusionEndurance, resistance and combined training might improve sperm parameters, including viability and motility of sperms through increasing the serum testosterone and LH levels in rat model of diabetes mellitus type 2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.