Evidence map›Paper›PMID 31890320›Full record

ArticleApplied sciences (Basel, Switzerland)2019

The Evolution of Tissue Engineered Vascular Graft Technologies: From Preclinical Trials to Advancing Patient Care.

Yuichi Matsuzaki, Kelly John, Toshihiro Shoji, Toshiharu Shinoka

Abstract read
In one paragraph

Article in Applied sciences (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

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  13. The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuichi MatsuzakiCenter for Regenerative Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Kelly JohnCenter for Regenerative Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Toshihiro ShojiCenter for Regenerative Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Toshiharu ShinokaCenter for Regenerative Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0002-5173-9249

Funding

Training in Congenital and Acquired Heart DiseaseT32HL098039 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU, MOHLER, PETER J. · 2009 to 2019
$2.5M
NHLBI NIH HHS T32 HL098039
6 · The paper itself

Abstract

Currently available synthetic grafts have contributed to improved outcomes in cardiovascular surgery. However, the implementation of these graft materials at small diameters have demonstrated poor patency, inhibiting their use for coronary artery bypass surgery in adults. Additionally, when applied to a pediatric patient population, they are handicapped by their lack of growth ability. Tissue engineered alternatives could possibly address these limitations by producing biocompatible implants with the ability to repair, remodel, grow, and regenerate. A tissue engineered vascular graft (TEVG) generally consists of a scaffold, seeded cells, and the appropriate environmental cues (i.e., growth factors, physical stimulation) to induce tissue formation. This review critically appraises current state-of-the-art techniques for vascular graft production. We additionally examine current graft shortcomings and future prospects, as they relate to cardiovascular surgery, from two major clinical trials.

Indexed as

arteriovenous shuntsbiodegradable materialcongenital heart surgerytissue-engineered vascular grafts

Identifiers

PMID31890320
PMCPMC6937136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.