ArticleJournal of intensive care2019
Role of serial lactate measurement to predict 28-day mortality in patients undergoing emergency laparotomy for perforation peritonitis: prospective observational study.
Article in Journal of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Artificial intelligence for predicting 30-day mortality after emergency laparotomy.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Development and Validation of Machine Learning Models for Predicting 7-Day Mortality in Critically Ill Patients with Traumatic Spinal Cord Injury: A Multicenter Retrospective Study.Neurocritical care · 2026Article
- Article
- Literature Review of Prognostic Factors in Secondary Generalized Peritonitis.Life (Basel, Switzerland) · 2025Review
- Combination of radiomic and clinical characteristics to predict mortality in patients with colorectal perforation.International journal of colorectal disease · 2025Article
- Emergency laparotomy preoperative risk assessment tool performance: A systematic review.Surgery in practice and science · 2024Review
- Epidemiology and Long-term Outcomes of Acute Kidney Injury in Adult Patients with Perforation Peritonitis Undergoing Emergency Laparotomy.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Ultrasonographic assessment of brachial artery reactivity as a predictor of adverse outcome in patients undergoing emergency laparotomy for perforated peritonitis - Prospective observational study.Indian journal of anaesthesia · 2023Article
- Esophagram should be performed to diagnose esophageal perforation before inter-hospital transfer.Journal of thoracic disease · 2023Article
- Association between Intraoperative Early Warning Score and Mortality and In-Hospital Stay in Lower Gastrointestinal Spontaneous Perforation.Anesthesiology research and practice · 2023Article
- Admission Lactate Concentration, Base Excess, and Alactic Base Excess Predict the 28-Day Inward Mortality in Shock Patients.Journal of clinical medicine · 2022Article
- Patient outcomes and prognostic factors associated with colonic perforation surgery: a retrospective study.Journal of Yeungnam medical science · 2022Article
- Intraoperative lung protective ventilation in peritonitis patients undergoing emergency laparotomy: A randomised controlled trial.Indian journal of anaesthesia · 2021Article
- Machine Learning-based Model for Predicting Postoperative Complications among Patients with Colonic Perforation: A Retrospective study.Journal of the anus, rectum and colon · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerial lactate measurement is found to predict mortality in septic shock. Majority of patients with perforation peritonitis for emergency laparotomy are in sepsis and mortality rate is substantial. However, lactate dynamics has not been studied in this patient population.
methodsAfter institutional ethics clearance and informed written consent, 113 patients with suspected or proven perforation peritonitis presenting for emergency laparotomy were recruited in this prospective observational trial. Baseline Mannheim peritonitis index (MPI), SOFA and APACHE II score were calculated. Lactate values were obtained at baseline, immediate and 24-h postoperative period. Primary outcome was 28-day mortality.
resultsMortality was 15.04% at 28 days. Age, SOFA, qSOFA, APACHE, preoperative lactate, MPI and site of perforation were significantly different between survivors and non-survivors. Arterial lactate values at preoperative (cut off 2.75 mmol/L), immediate postoperative (cut off 2.8 mmol/L) and 24 h-postoperative period (cut off 2.45 mmol/L) independently predicted mortality at day 28. Combination of MPI and 24-h lactate value was best predictor of mortality with AUC 0.99.
conclusionPreoperative, immediate postoperative and 24-h postoperative lactate value independently predict 28-day mortality in perforation peritonitis patients undergoing emergency laparotomy. Combination of MPI and 24-h lactate value is the most accurate predictor of mortality.
trial registrationClinical Trial Registry of India - CTRI/2018/01/011103.
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