ArticleEvolution, medicine, and public health2019
Experimental evolution of gallium resistance in
Article in Evolution, medicine, and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Triple Threat: Elucidating Evolution Under Antibiotic, Metal, and Phage Pressure inEcology and evolution · 2026Article
- Resisting the gallium "Trojan horse": Experimental evolutionary insights into microbial resistance.Gene & protein in disease · 2026Article
- Opposing roles for iron transport systems in gallium tolerance in extraintestinal pathogenicJournal of bacteriology · 2025Article
- Phage Resistance ModulatesAntibiotics (Basel, Switzerland) · 2025Article
- Antibacterial activity and mechanistic insights of gallium-based nanoparticles: an emerging frontier in metal-based antimicrobials.RSC advances · 2025Review
- Gallium Resistance inApplied microbiology (Basel, Switzerland) · 2025Article
- Escherichia coli growing under antimicrobial gallium nitrate stress reveals new processes of tolerance and toxicity.Scientific reports · 2025Article
- Survival, resistance, and fitness dynamics ofEvolution, medicine, and public health · 2025Article
- Gallium: a decisive "Trojan Horse" against microorganisms.Antonie van Leeuwenhoek · 2024Review
- Nanotechnology-A Light of Hope for Combating Antibiotic Resistance.Microorganisms · 2023Article
- Serving Two Masters: Effect ofAntibiotics (Basel, Switzerland) · 2023Article
- Genomics of Diversification of Pseudomonas aeruginosa in Cystic Fibrosis Lung-like Conditions.Genome biology and evolution · 2022Article
- Experimental Evolution of Copper Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Genome mining to unravel potential metabolic pathways linked to gallium bioleaching ability of bacterial mine isolates.Frontiers in microbiology · 2022Article
- Experimental Evolution of Magnetite Nanoparticle Resistance inNanomaterials (Basel, Switzerland) · 2021Article
- Gain-of-Function Mutations in Acid Stress Response (Antimicrobial agents and chemotherapy · 2021Article
- Too much of a good thing: Adaption to iron (II) intoxication inEvolution, medicine, and public health · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesMetallic antimicrobial materials are of growing interest due to their potential to control pathogenic and multidrug-resistant bacteria. Yet we do not know if utilizing these materials can lead to genetic adaptations that produce even more dangerous bacterial varieties. METHODOLOGY: Here we utilize experimental evolution to produce strains of
resultsBy day 10 of evolution, increased gallium resistance was evident in populations cultured in medium containing a sublethal concentration of gallium. Furthermore, these populations showed increased resistance to ionic silver and iron (III), but not iron (II) and no increase in traditional antibiotic resistance compared with controls and the ancestral strain. In contrast, the control populations showed increased resistance to rifampicin relative to the gallium-resistant and ancestral population. Genomic analysis identified hard selective sweeps of mutations in several genes in the gallium (III)-resistant lines including:
conclusionsThis study corroborates recent results observed in experiments utilizing pathogenic LAY SUMMARY: We utilize experimental evolution to produce strains of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.