Evidence map›Paper›PMID 31890139›Full record

ReviewComputational and structural biotechnology journal2020

Long walk to genomics: History and current approaches to genome sequencing and assembly.

Alice Maria Giani, Guido Roberto Gallo, Luca Gianfranceschi, Giulio Formenti

Open access · goldAbstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 310 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. The complete genome of a songbird.bioRxiv : the preprint server for biology · 2025
    Article
  13. Evaluation of sequencing reads at scale using rdeval.Bioinformatics (Oxford, England) · 2025
    Article
  14. Longitudinal big biological data in the AI era.Molecular systems biology · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Transgene Mapping in Animals: What to Choose?International journal of molecular sciences · 2025
    Review
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Alice Maria GianiDepartment of Surgery, Weill Cornell Medical College, New York, NY, USA.
Guido Roberto GalloDepartment of Biosciences, University of Milan, Milan, Italy.
Luca GianfranceschiDepartment of Biosciences, University of Milan, Milan, Italy.
Giulio FormentiThe Rockefeller University, New York, NY, USA.
University of Milan · ITCornell University · USRockefeller University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomes represent the starting point of genetic studies. Since the discovery of DNA structure, scientists have devoted great efforts to determine their sequence in an exact way. In this review we provide a comprehensive historical background of the improvements in DNA sequencing technologies that have accompanied the major milestones in genome sequencing and assembly, ranging from early sequencing methods to Next-Generation Sequencing platforms. We then focus on the advantages and challenges of the current technologies and approaches, collectively known as Third Generation Sequencing. As these technical advancements have been accompanied by progress in analytical methods, we also review the bioinformatic tools currently employed in

Indexed as

BAC, Bacterial Artificial ChromosomeBioinformaticsbp, base pairddNTP, 2,3-dideoxynucleoside triphosphatedNTPs, deoxynucleoside triphosphatesGenome assemblyHapMap, haplotype mapHGP, Human Genome ProjectHMW, high molecular weightNext-generationNGS, Next Generation SequencingOLC, Overlap-Layout-ConsensusQV, Quality Value (QV)ReferenceSBS, Sequencing by SynthesisSequencingSMRT, Single Molecule Real-TimeSNPs, Single Nucleotide PolymorphismsSRA, Short Read ArchiveSV, Structural VariantTGS, Third Generation SequencingThird-generationWGS, Whole Genome SequencingZMW, Zero-Mode Waveguide

Identifiers

PMID31890139
PMCPMC6926122
OpenAlexW2988628263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.