ArticleDiabetology & metabolic syndrome2019
Age-specific diabetes risk by the number of metabolic syndrome components: a Korean nationwide cohort study.
Article in Diabetology & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Trends of cause-specific cardiovascular disease mortality in China, 2009-2019: a nationwide longitudinal study.Annals of medicine · 2025Article
- Sex- and age-specific determinants of diabetes: Insights from BKMR and cox modelling of metabolic and lifestyle risk factors in a Korean cohort.Diabetes, obesity & metabolism · 2025Article
- Article
- Iron Homeostasis-Related Parameters and Hepcidin/Ferritin Ratio: Emerging Sex-Specific Predictive Markers for Metabolic Syndrome.Metabolites · 2024Article
- Risk of developing chronic kidney disease in young-onset Type 2 diabetes in Korea.Scientific reports · 2023Article
- Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes.Diabetology & metabolic syndrome · 2023Article
- Long Working Hours and the Risk of Glucose Intolerance: A Cohort Study.International journal of environmental research and public health · 2022Article
- Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need.The Korean journal of internal medicine · 2021Review
- Subtypes of Premorbid Metabolic Syndrome and Associated Clinical Outcomes in Older Adults.Frontiers in medicine · 2021Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic syndrome is associated with an increased risk of diabetes. This study investigated the associations between the number of metabolic syndrome components and diabetes risk by age, sex and BMI.
methodsData for 19,475,643 participants ≥ 20 years old with no history of diabetes were obtained between 2009 and 2012 and were accessed using the South Korean National Health Insurance Service. Metabolic syndrome was defined according to the modified criteria of the National Cholesterol Education Program Adult Treatment Panel III. We assessed the risk of diabetes according to the number of metabolic syndrome components after stratifying the study participants into groups by age (20-39, 46-64, ≥ 65 years), sex, and BMI (below or above 25).
resultsDuring an average of 5.13 years of follow-up, the incidence rates of diabetes increased with the number of metabolic syndrome components. Age and BMI gradually increased with the number of metabolic syndrome components. The multivariable-adjusted hazard ratios (HRs) for incident diabetes were 1.401, 1.862, 2.47, 3.164 and 4.501 for participants with one through five components, respectively, compared with those without metabolic syndrome components. The risk of diabetes was 1.79-, 2.18-, and 3.05-times higher for participants ≥ 65 years; 2.57-, 3.45-, and 5.18-times higher for participants 40-64 years; and 2.55-, 3.89-, and 6.31-times higher for participants 20-39 years of age with three through five components, respectively, compared to those with no components. There was no difference in the risk of diabetes between men and women. The HRs were 5.63 for participants with a BMI ≥ 25 and 3.98 for those with a BMI < 25 among individuals with five components.
conclusionsThe risk of diabetes was more strongly associated with the number of metabolic syndrome components among younger adults. In addition, the risk of diabetes across the number of metabolic syndrome components was greater in participants with a BMI ≥ 25.
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