ArticleDiabetology & metabolic syndrome2019
Cost effectiveness of different screening strategies for gestational diabetes mellitus screening: study protocol of a randomized community non-inferiority trial.
Article in Diabetology & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Suboptimal gestational weight gain and neonatal outcomes in low and middle income countries: individual participant data meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Risk factors for inadequate and excessive gestational weight gain in 25 low- and middle-income countries: An individual-level participant meta-analysis.PLoS medicine · 2023Pooled it
- Various screening and diagnosis approaches for gestational diabetes mellitus and adverse pregnancy outcomes: a secondary analysis of a randomized non-inferiority field trial.BMJ open diabetes research & care · 2023Trial
- Does fasting plasma glucose values 5.1-5.6 mmol/l in the first trimester of gestation a matter?Frontiers in endocrinology · 2023Trial
- Umbilical cord blood concentration of connecting peptide (C-peptide) and pregnancy outcomes.BMC pregnancy and childbirth · 2022Trial
- One-step versus two-step screening for diagnosis of gestational diabetes mellitus in Iranian population: A randomized community trial.Frontiers in endocrinology · 2022Trial
- Universal versus risk- factor-based screening for gestational diabetes mellitus: findings from a large-scale cohort study.Frontiers in endocrinology · 2026Article
- Gestational weight gain and maternal immediate perinatal and postpartum outcomes in low and middle income countries: individual participant data meta-analyses.BMJ medicine · 2026Article
- Iranian Endocrine Society Guidelines for Screening, Diagnosis, and Management of Gestational Diabetes Mellitus.International journal of endocrinology and metabolism · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is lack of ideal and comprehensive economic evaluations of various GDM strategies. The aim of this study is to the compare efficacy and cost-effectiveness of five different methods of screening for gestational diabetes mellitus (GDM).
methodsThis study is a randomized community non-inferiority trial among 30,000 pregnant women in five different geographic regions of Iran, who were randomly assigned to one of the five GDM screening methods. All first trimester pregnant women, seeking prenatal care in governmental health care systems, who met our eligibility criteria were enrolled. The criteria suggested by the International-Association-of-Diabetes-in-Pregnancy-Study-Group, the most intensive approach, were used as reference. We used the non-inferiority approach to compare less intensive strategies to the reference one. Along with routine prenatal standard care, all participants were scheduled to have two phases of GDM screening in first and second-trimester of pregnancy, based on five different pre-specified protocols. The screening protocol included fasting plasma glucose in the first trimester and either a one step or a two-step screening method in the second trimester of pregnancy. Pregnant women were classified in three groups based on the results: diagnosed with preexisting pre-gestational overt diabetes; gestational diabetes and non-GDM women. Each group received packages for standard-care and all participants were followed till delivery; pregnancy outcomes, quality of life and cost of health care were recorded in detail using specific standardized questionnaires. Primary outcomes were defined as % birth-weight > 90th percentile and primary cesarean section. In addition, we assessed the direct health care direct and indirect costs.
resultsThis study will enable us to compare the cost effectiveness of different GDM screening protocols and intervention intensity (low versus high).
conclusionResults which if needed, will also enable policy makers to optimize the national GMD strategy as a resource for enhancing GDM guidelines.
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Registered trials
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