Evidence map›Paper›PMID 31889893›Full record

ArticleCancer cell international2019

Correlations between chromobox homolog 8 and key factors of epithelial-mesenchymal transition in hepatocellular carcinoma.

Xiaonian Zhu, Wei Luo, Chunhua Bei, Juan Kong, Shidong Zhang, Yuanyuan Fu, Di Li, Shengkui Tan

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaonian Zhu1Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, Guilin, 541004 Guangxi People's Republic of China.ORCID 0000-0002-6175-3204
Wei Luo2Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, 637000 Sichuan People's Republic of China.
Chunhua Bei1Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, Guilin, 541004 Guangxi People's Republic of China.
Juan Kong1Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, Guilin, 541004 Guangxi People's Republic of China.
Shidong Zhang1Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, Guilin, 541004 Guangxi People's Republic of China.
Yuanyuan Fu1Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, Guilin, 541004 Guangxi People's Republic of China.
Di Li1Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, Guilin, 541004 Guangxi People's Republic of China.
Shengkui Tan1Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, Guilin, 541004 Guangxi People's Republic of China.ORCID 0000-0002-1955-0868
Guilin Medical University · CNNorth Sichuan Medical University · CN

Funding

Key Science and Technology Research and Development Program Project of Guangxi AB17292074National Natural Science Foundation of China 81860586National Natural Science Foundation of China 81860602Natural Science Foundation of Guangxi Province 2018GXNSFAA281054Natural Science Foundation of Guangxi Province 2018GXNSFBA281216
6 · The paper itself

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in China, with high metastasis and poor prognosis. Recently, as the core component of the polycomb repressive complexes 1 (PRC1), chromobox protein homolog 8 (CBX8) is considered as an oncogene and prognostic marker in HCC. Methods: A tissue microarray of 166 paired HCC and adjacent non-tumor samples were collected to identify the relationship between CBX8 and epithelial mesenchymal transition (EMT) associated proteins by Spearman correlation analysis. Knock-down of CBX8 in HCC cells was conducted to detect the biologic functions of CBX8 in HCC metastasis. Results: We found out that CBX8 was over-expressed in HCC and its expression was closely related to the metastasis of HCC patients. In addition, knock-down of CBX8 was found to inhibit the invasion and migration ability of HCC cells. Moreover, there was a significant relationship between expression of CBX8 and EMT associated proteins both in HCC cells and tumor tissues. Conclusions: Our results indicate that CBX8 promotes metastasis of HCC by inducing EMT process.

Indexed as

Chromobox protein homolog 8Epithelial mesenchymal transitionHepatocellular carcinomaMetastasis

Identifiers

PMID31889893
PMCPMC6916084
OpenAlexW2996290347

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.